90 Abstract Introduction: Contrast-induced nephropathy is one of the main causes of acute kidney injury and increased hospital-acquired morbidity and mortality. The use of sodium bicarbonate for nephroprotection has emerged as a preventative strategy; however, its efficacy is controversial compared to other strategies, such as hydration using 0.9% saline solution. Objective: To compare the effe...

BACKGROUND Cilastatin reduces nephrotoxicity associated with cyclosporin A (CyA) in solid organ and bone marrow transplantation. This appears to be unrelated to changes in renal haemodynamics or CyA metabolism. How cilastatin induces this protection is unclear, but it could result from changes on accumulation of CyA proximal cells. METHODS We investigated the effects of cilastatin on primary ...

PURPOSE Tubular secretion of cisplatin is abolished in mice deficient for the organic cation transporters Oct1 and Oct2 (Oct1/2(-/-)mice), and these animals are protected from severe cisplatin-induced kidney damage. Since tubular necrosis is not completely absent in Oct1/2(-/-)mice, we hypothesized that alternate pathways are involved in the observed injury. EXPERIMENTAL DESIGN Studies were d...

Over the last few years, there has been an increasing trend in prevalence of chronic kidney diseases (CKD) patients with heart failure (CHF). CKD is a well-known comorbidity failure, associated lower survival rates, while cardiovascular complications are leading cause death among CKD. The ability to identify early CHF critical for estimating prognosis, developing treatment strategy and tactics,...