نتایج جستجو برای: environmental catastrophe 132 percent
تعداد نتایج: 483178 فیلتر نتایج به سال:
The G(2) DNA damage checkpoint is activated by genotoxic agents and is particularly important for cancer therapies. Overriding the checkpoint can trigger precocious entry into mitosis, causing cells to undergo mitotic catastrophe. But some checkpoint-abrogated cells can remain viable and progress into G(1) phase, which may contribute to further genome instability. Our previous studies reveal th...
Genotoxic stress such as ionizing radiation halts entry into mitosis by activation of the G(2) DNA damage checkpoint. The CHK1 inhibitor 7-hydroxystaurosporine (UCN-01) can bypass the checkpoint and induce unscheduled mitosis in irradiated cells. Precisely, how cells behave following checkpoint abrogation remains to be defined. In this study, we tracked the fates of individual cells after check...
Catastrophe theory is a mathematical formalism for modeling nonlinear systems whose discontinuous behavior is determined by smooth changes in a small number of driving parameters. Fitting a catastrophe model to noisy data constitutes a serious challenge, however, because catastrophe theory was formulated specifically for deterministic systems. Loren Cobb addressed this challenge by developing a...
Recent developments in computer technology have significantly altered the way the insurance business functions. Easy access to large quantities of data has rendered some traditional ratemaking limitations obsolete. The emergence of catastrophe simulation using computer modeling has helped actuaries develop new methods for measuring catastrophe risk and providing for it in insurance rates. This ...
This paper develops a two-gene, single fitness peak model for determining the equilibrium distribution of genotypes in a unicellular population which is capable of genetic damage repair. The first gene, denoted by sigma(via), yields a viable organism with first-order growth rate constant k>1 if it is equal to some target "master" sequence sigma(via,0). The second gene, denoted by sigma(rep), yi...
Environmental policies have brought dramatic improvements in air and water quality in the United States over the past 25 years, but further expansion of command-and-control regulations is likely to have diminishing marginal returns. Since the early 1990s corporations have taken new initiatives in managing their environmental impacts in ways that reduce their costs, increase their efficiency, lo...
Reef corals harbouring clade D Symbiodinium spp. (endosymbiotic dinoflagellates) appear more tolerant of environmental stress. As sea surface temperatures rise, symbioses involving Symbiodinium D may increase in prevalence. For this reason, eight polymorphic microsatellite loci were developed for clade D Symbiodinium. From the analysis of 132 samples originating from cnidarian hosts in the Atla...
BACKGROUND In March 2003, several hospitals in Quebec, Canada, noted a marked increase in the incidence of Clostridium difficile-associated diarrhea. METHODS In 2004 we conducted a prospective study at 12 Quebec hospitals to determine the incidence of nosocomial C. difficile-associated diarrhea and its complications and a case-control study to identify risk factors for the disease. Isolates o...
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