T951115 Page 2 Chromosome effects: No data gap, no adverse effect2 DNA damage: No data gap, no adverse effect Neurotoxicity: Not required at this time

Chromosome effects: No data gap, no adverse effect DNA damage: No data gap, possible adverse effect Neurotoxicity: Not required at this time

To establish a relevant in vitro model for systems toxicology-based mechanistic assessment of environmental stressors such as cigarette smoke (CS), we exposed human organotypic bronchial epithelial tissue cultures at the air liquid interface (ALI) to various CS doses. Previously, we compared in vitro gene expression changes with published human airway epithelia in vivo data to assess their simi...

The nematode Caenorhabditis elegans has emerged as an important animal model in various fields including neurobiology, developmental biology, and genetics. Characteristics of this animal model that have contributed to its success include its genetic manipulability, invariant and fully described developmental program, well-characterized genome, ease of maintenance, short and prolific life cycle,...

1Phytomedicine, Toxicology and Reproductive Biochemistry Research Laboratory, Department of Biochemistry, University of Ilorin, Ilorin 240003, Nigeria 2Phytomedicine, Environmental Toxicology and Plant Biochemistry Research Laboratory, Department of Biological Sciences, Al-Hikmah University, Ilorin 240001, Nigeria 3Department of Agriculture, Faculty of Applied Sciences, Cape Peninsula Universit...

J O N G S E O N G K H I M , † , ‡ K U R U N T H A C H A L A M K A N N A N , * , ‡ D A N I E L L . V I L L E N E U V E , ‡ C H U L H W A N K O H , † A N D J O H N P . G I E S Y ‡ Department of Oceanography, Seoul National University, Seoul 151-742, Korea, and National Food Safety and Toxicology Center, Department of Zoology, and Institute for Environmental Toxicology, Michigan State University, ...

1Department of Chemistry, Rutgers University, Camden, NJ, USA; Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, USA 2Johns Hopkins Bloomberg School of Public Health, Center for Alternatives to Animal Testing (CAAT), Baltimore, MD, USA 3National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of En...

1 Tufts Center for Regenerative and Developmental Biology. Tufts University, Department of Biology, 200 Boston Ave. Suite 4600, Medford, MA 02155 USA. [email protected] 2 Institut für Klinische Pharmakologie und Toxikologie, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany 3 Division of Extramural Research and Training, National Institute of Environmental H...