It is well-known that the Interparticle interactions between adsorbates and surface of an adsorbent can affect the surface morphology. One of the consequences of this issue is that the resonant frequency of a nanoscale resonator can be changed due to adsorption. In this study we have chosen a cantilever-based nanoscale mass-sensor with a single nanoparticle at its tip. Using the classical...

Post-translational addition of methyl groups to the amino terminal tails of histone proteins regulates cellular gene expression at various stages of development and the pathogenesis of cellular diseases, including cancer. Several enzymes that modulate these post-translational modifications of histones are promising targets for development of small molecule drugs. However, there is no promising ...

Glucokinase (GK) serves as glucose sensor in pancreatic -cells and in other glucose sensor cells in the body. Biochemical genetic studies have characterized many activating and inactivating GK mutants that have been discovered in patients with hyperinsulinemic hypoglycemia or diabetes, all inherited as autosomal dominant traits. Mathematical modeling of the kinetic data of recombinant human wil...

In this paper we focus on the application of reinforcement learning to obstacle avoidance in dynamic Environments in wireless sensor networks. A distributed algorithm based on reinforcement learning is developed for sensor networks to guide mobile robot through the dynamic obstacles. The sensor network models the danger of the area under coverage as obstacles, and has the property of adoption o...

One of the most important and typical application of wireless sensor networks (WSNs) is target tracking. Although target tracking, can provide benefits for large-scale WSNs and organize them into clusters but tracking a moving target in cluster-based WSNs suffers a boundary problem. The main goal of this paper was to introduce an efficient and novel mobility management protocol namely Target Tr...

Sybil attacks pose a serious threat for Wireless Sensor Networks (WSN) security. They can create problems in routing, voting schemes, decision making, distributed storage and sensor re-programming. In a Sybil attack, the attacker masquerades as multiple sensor identities that are actually controlled by one or a few existing attacker nodes. Sybil identities are fabricated out of stolen keys, obt...

Advances in low-power electronics design and wireless communication have enabled the development of low cost, low power micro-sensor nodes. These sensor nodes are capable of sensing, processing and forwarding which have many applications such as underwater networks. In underwater wireless sensor networks (UWSNs) applications, sensors which are placed in underwater environments and predicted ena...

A series of dopant-type polyaniline-polyacrylic acid composite (PAn-PAA) films with porous structures were prepared and developed for an enzyme-free hydrogen peroxide (H(2)O(2)) sensor. The composite films were highly electroactive in a neutral environment as compared to polyaniline (PAn). In addition, the carboxyl group of the PAA was found to react with H(2)O(2) to form peroxy acid groups, an...

We report herein the development of a simple, sensitive colorimetric magnetic nanoparticle (MNP)-enzyme-based DNA sandwich assay that is suitable for simultaneous, label-free quantitation of two DNA targets down to 50 fM level. It can also effectively discriminate single-nucleotide polymorphisms (SNPs) in genes associated with human cancers (KRAS codon 12/13 SNPs). This assay uses a pair of spe...