in recent years, the cloning technology has remarkably developed iran, but unfortunately, the required legal framework has not been created to support and protect such developments yet. this legal gap may lead to abuse of scientific researches to obtain illegal benefits and to undermine the intellectual property rights of scientists and researchers. thus to prevent such consequences, the attemp...

Domestic animals can be cloned using techniques such as embryo splitting and nuclear transfer to produce genetically identical individuals. Although embryo splitting is limited to the production of only a few identical individuals, nuclear transfer of donor nuclei into recipient oocytes, whose own nuclear DNA has been removed, can result in large numbers of identical individuals. Moreover, clon...

monogenic traits has become nearly trivial, the molecular dissection of multifactorial traits—which include the majority of medically and agronomically important phenotypes—remains a major challenge. Despite the substantial resources that have been allocated to such efforts—particularly in human—a recent survey reported only 30 successful outcomes, all organisms confounded (Glazier et al. 2002)...

t-shape profile barriers are one of the most successful barriers among many different profiles. it has been shown that using welled diffusers on the top of t-shaped barriers makes a reactive barrier that shows better performance than that of any other used profile barriers compared with their equivalent absorbent barrier. the contribution of the top surface of reactive t-profile barriers to the...

the aim of this study was to investigate the barrier properties of cellulose nanocrystals-pvananocomposites. nanocomposite films with different filler loading levels (3, 6, 9 and 12% by wt) weredeveloped by solvent casting method. the effect of cellulose nanocrystals on the barrier properties ofthe nanocomposites was studied. to this end, moisture absorption, water vapor permeability (wvp),oxyg...

The low success rate of animal cloning by somatic cell nuclear transfer (SCNT) associates with epigenetic aberrancy, including the abnormal acetylation of histones. Altering the epigenetic status by histone deacetylase inhibitors (HDACi) enhances the developmental potential of SCNT embryos. In the current study, we examined the effects of LBH589 (panobinostat), a novel broad-spectrum HDACi, on ...

Establishment of a human model of the blood-brain barrier has proven to be a difficult goal. To accomplish this, normal human brain endothelial cells were transduced by lentiviral vectors incorporating human telomerase or SV40 T antigen. Among the many stable immortalized clones obtained by sequential limiting dilution cloning of the transduced cells, one was selected for expression of normal e...