Submit Manuscript | http://medcraveonline.com Abbrevations: CNS: Central Nervous System; NREM: NonRapid Eye Movement; REM: Rapid Eye Movement; vEEG: Video Electroencephalography; PSG: Polysomnography; IED: Interictal Epileptiform Discharges; SSMA: Supplementary Sensorimotor Area; JME: Juvenile Myoclonic Epilepsy; TLE: Temporal Lobe Epilepsies; NTLE: Nocturnal Temporal Lobe Epilepsy; SW: SpikeWa...

It is still poorly understood how epileptiform events can recruit cortical circuits. Moreover, the speed of propagation of epileptiform discharges in vivo and in vitro can vary over several orders of magnitude (0.1-100 mm/s), a range difficult to explain by a single mechanism. We previously showed how epileptiform spread in neocortical slices is opposed by a powerful feedforward inhibition ahea...

Martı́n, Eduardo D., Alfonso Araque, and Washington Buño. Synaptic regulation of the slow Ca-activated K current in hippocampal CA1 pyramidal neurons: implication in epileptogenesis. J Neurophysiol 86: 2878–2886, 2001. The slow Ca-activated K current (sIAHP) plays a critical role in regulating neuronal excitability, but its modulation during abnormal bursting activity, as in epilepsy, is unknown...

Cortical and hippocampal network hyperexcitability appears to be an early event in Alzheimer's disease (AD) pathogenesis, and may contribute to memory impairment. It remains unclear if network hyperexcitability precedes memory impairment in mouse models of AD and what are the underlying cellular mechanisms. We thus evaluated seizure susceptibility and hippocampal network hyperexcitability at ~3...

To elucidate the mechanism underlying epileptiform discharges in kindled rats, synaptic responses in kindled basolateral amygdala neurons in vitro were compared with those from control rats by using intracellular and whole cell patch-clamp recordings. In kindled neurons, electrical stimulation of the stria terminalis induced epileptiform discharges. The resting potential, apparent input resista...

Epileptogenic action of penicillin (PC) was investigated in thin slices prepared from the guinea-pig hippocampus. Bath-applied PC (1.7 mM) provoked an epileptiform activity. A series of cellular events before during and after application of PC were shown by stable intracellular recording from the same neuron. The effect of PC became progressively pronounced when the temperature of the medium wa...

Epilepsy is an important problem in neurological disorders. The common features of all types of epilepsy are the synchronized and uncontrolled discharges of nerve cell assemblies. Recent studies claimed that gap junctions have a critical role in epileptic neuronal events. The aim of present study is to investigate the effects of connexin36 (Cx36) channel blocker quinine on penicillin-induced ex...