نتایج جستجو برای: epoxide hydrolase

تعداد نتایج: 26425  

2001
Larry W. Robertson Paul E. Thomas Dene E. Ryan Wayne Levin

Antibodies against cytochromes P-450a, P-450b + P450e, P-450c, and P-450d and epoxide hydrolase were utilized in a radial immunodiffusion assay to measure the concentration of these inducible, xenobiotic-metabolizing enzymes in liver microsomes from rats treated with Aroclor 1254, fireMaster BP-6, or one of 41 individual polychlorinated and polybrominated biphenyl isomers and congeners. Cy...

Journal: :Molecular pharmacology 2006
A L Slitt N J Cherrington M Z Dieter L M Aleksunes G L Scheffer W Huang D D Moore C D Klaassen

trans-Stilbene oxide (TSO) induces drug metabolizing enzymes in rat and mouse liver. TSO is considered a phenobarbital-like compound because it induces Cyp2B mRNA expression in liver. Phenobarbital increases Cyp2B expression in liver via activation of the constitutive androstane receptor (CAR). The purpose of this study was to determine whether TSO induces gene expression in mouse liver via CAR...

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