NMDA receptor (NMDAR) subunits epsilon 1-epsilon 4 are expressed differentially with respect to brain region and ontogenic period, but their functional roles still are unclear. We have compared an epsilon 1 subunit-ablated mutant mouse with the wild-type to characterize the effect of epsilon subunit expression on NMDAR-mediated single-channel currents and synaptic currents of granule cells in c...

Motivated by estimation of quantum noise models, we study the problem learning a Pauli channel, or more generally error rates an arbitrary channel. By employing novel reduction to "Population Recovery" problem, give extremely simple algorithm that learns $n$-qubit channel precision $\epsilon$ in $\ell_\infty$ using just $O(1/\epsilon^2) \log(n/\epsilon)$ applications This is optimal up logarith...

Unique among the phospholipase C isozymes, the recently identified phospholipase C-epsilon (PLC-epsilon) contains an amino-terminal CDC25 domain capable of catalyzing nucleotide exchange on Ras family GTPases as well as a tandem array of Ras-associating (RA) domains near its carboxyl terminus that are effector binding sites for activated H-Ras and Rap. To determine whether other small GTPases a...

When introduced as part of DNA constructions containing the human beta-globin locus control region (LCR), the human embryonic beta-globin gene, epsilon, is expressed in primitive but not definitive erythroid cells of recipient transgenic mice. In contrast to this pattern, the human fetal beta-globin gene, gamma, has been shown to be expressed in both primitive and definitive erythroid cells of ...

Dynamic Monte Carlo simulation of a bead-spring model of flexible macromolecules threading through a very narrow pore in a very thin rigid membrane are presented, assuming at the cis side of the membrane a purely repulsive monomer-wall interaction, while the trans side is attractive. Two choices of monomer-wall attraction epsilon are considered, one choice is slightly below and the other slight...

This study was performed to elucidate the relation between in vivo measurements of two-dimensional principal strains and the progression of left ventricle (LV) wall thinning during development of dilated cardiomyopathy in the protein kinase C-epsilon (PKC-epsilon) transgenic (TG) overexpressing mouse heart. Principal two-dimensional strains, E1 and E2, were determined in the LV wall of the anes...

For any compact connected manifold $M$, we consider the generalized contact Hamiltonian $H(x,p,u)$ defined on $T^*M\times\mathbb R$ which is conex in $p$ and monotonically increasing $u$. Let $u_\epsilon^-:M\rightarrow\mathbb be viscosity solution of parametrized Hamilton-Jacobi equation \[ H(x,\partial_x u_\epsilon^-(x),\epsilon u_\epsilon^-(x))=c(H) \] with $c(H)$ being Ma\~n\'e Critical Valu...

Members of the human beta-globin gene family are expressed at discrete stages of development and therefore provide an important model system for examining mechanisms of temporal gene regulation. We have previously shown that expression of the embryonic beta-like globin gene (epsilon) is mediated by a complex array of positive and negative upstream control elements. Correct developmental stage- ...