We evaluated the therapeutic potential of a sustained nitric oxide (NO)-releasing compound to correct the molecular hallmarks and pathophysiology of priapism, an important but poorly characterized erectile disorder. 1,5-Bis-(dihexyl-N-nitrosoamino)-2,4-dinitrobenzene (C6') and an inactive form of the compound [1,5-bis-(dihexylamino)-2,4-dinitrobenzene (C6)] were tested in neuronal cell cultures...

Introduction: It has been suggested that paradoxical sleep deprivation (PSD) could sensitize dopaminergic systems, probably by inducing supersensitivity of the post synaptic receptor (TUFIK et al., 1978). The mesolimbic dopamine (DA) system, composed of DAergic neurons in the ventral tegmental area and their projections to the nucleus accumbens and other forebrain structures, has been implicate...

Erectile dysfunction is the most common side effect after prostatectomy. There are currently five categories of available treatment options for erectile dysfunction for men following radical prostatectomy. The first and most common treatment is oral phosphodiesterase type 5 inhibitors (sildenafil, vardenafil, or tadalafil). Despite their popularity, these medications do not always produce an er...

Rapid eye movement sleep in males is characterized by penile erection along with EEG desynchronization, muscle atonia, ponto-geniculo-occipital waves, and rapid eye movements (REM). The central neural mechanisms regulating sleep related erections (SREs) are not known. Recently, the lateral preoptic area has been shown to contribute in sleep-related erectile mechanisms. The present study was con...

Erectile dysfunction (ED) is defined as the consistent inability to obtain or maintain an erection for satisfactory sexual relations. An estimated 20-30 million men suffer from some degree of sexual dysfunction. The past 20 years of research on erectile physiology have increased our understanding of the biochemical factors and intracellular mechanisms responsible for corpus cavernosal smooth mu...

Paper goal is to determine complications after urgent surgical treatment of patient with penile fractures, by using circumferential-degloving technique (degloving penile skin to root of penis). In period between 1998-2006 year, 23 patients have been treated as urgent cases with clinically proven penis fracture, age between 18 and 35. Patients were treated in 3 medical centers in Bosnia and Herz...

In 2002, the construction industry had the undesirable distinction of having two of the most dangerous occupations in the United States, with fatalities among structural steel workers at 58.2 fatalities per 100,000 workers (4 highest rate) and construction laborers experiencing fatalities at the rate of 27.7 fatalities per 100,000 workers (9 highest rate). In addition to the costs associated wi...