Understanding and managing leprosy reactions and their associated nerve function impairment remain a research priority for WHO and form part of the International Federation of Anti Leprosy Associations (ILEP) Strategy 2015-18. We still lack the tools to predict who will develop these serious complications which lead to nerve function impairment, disability and other long term sequelae, such as ...

ADDENDUM.-Since the preparation of this paper we have included in our battery of chemotherapeutic agents " epodyl " (I.C.I.) and vincaleukoblastine, on the advice of Mr. L. Walsh, of Atkinson Morley's Hospital, and Mr. K. Till, at Great Ormond Street, respectively. In the five gliomata tested (four astrocytomata and one ependymoma) vincaleukoblastine has proved very cytotoxic but occasionally v...

Leprosy is a disease caused by Mycobacterium leprae where the clinical spectrum correlates with the patient immune response. Erythema Nodosum Leprosum (ENL) is an immune-mediated inflammatory complication, which causes significant morbidity in affected leprosy patients. The underlying cause of ENL is not conclusively known. However, immune-complexes and cell-mediated immunity have been suggeste...

OBJECTIVES In this study, we investigated the clinical features, etiology, and also predictive factors of secondary erythema nodosum (EN) in patients with EN. METHODS A total of 100 patients (mean age: 37 years) diagnosed with EN between 1993 and 2004 in our clinic were included in the study prospectively. A skin biopsy was performed in 46 of the patients. Patients were considered to have sec...

Dear Editor, Methylmalonic acidemia, one of the organic acidemias, is associated with a variety of clinical presentations ranging from very sick newborn infants to asymptomatic adults, regardless of the nature of the enzymatic defect or the biochemical abnormalities. A 6-year-old boy with a past history of methylmalonic acidemia presented to the emergency room with a one-week history of inflamm...

Case report In March 1959, a 36-year-old woman was referred with a 2-month history of EN and a chest X-ray showing bilateral hilar lymphadenopathy (BHL), enlarged paratracheal lymph nodes and extensive bilateral nodular pulmonary infiltration. The Heaf test was weakly positive (grade I). A diagnosis of sarcoidosis was made. The EN resolved quickly and chest X-rays showed progressive regression ...

BACKGROUND Hepatitis C Virus (HCV) has estimated affected nearly 3% of the world population. Studies in Pakistan have shown a somewhat higher prevalence. The objective of this study was to determine the frequency of hepatitis C virus infection in patients with dermatological disorders, known to be associated with HCV infection. METHOD This was a descriptive study, conducted at Departments of ...