By analyzing, in parallel, large literature-derived and high-throughput experimental datasets we investigate genes harboring human inherited disease mutations in the context of molecular interaction networks. Our results demonstrate that network properties influence the likelihood and phenotypic consequences of disease mutations. Genes with intermediate connectivities have the highest probabili...

To investigate the origin and evolution of essential genes, we identified and phenotyped 195 young protein-coding genes, which originated 3 to 35 million years ago in Drosophila. Knocking down expression with RNA interference showed that 30% of newly arisen genes are essential for viability. The proportion of genes that are essential is similar in every evolutionary age group that we examined. ...

conclusions gorham’s disease has several manifestations as primary bone involvement. as in this rare case the ulna may be affected first and then the disease may spread to adjacent bones. more studies are needed to better recognize the behavior of this rare disease. introduction gorham’s disease is a rare musculoskeletal disease which causes progressive osteolysis and is characterized by massiv...

this study was performed to assess the effects of nitrogen fertilizer and vermicompost on qualitative and quantitative yield of chamomile ( matricaria chamomilla l.). it was conducted at the research fields of ran company located in firouzkouh, iran, in 2013. treatments were consisted of 1) control, 2) 100% nitrogen from urea, 3) 100% nitrogen from ammonium nitrate, 4) 75% nitrogen from urea an...

objective: this study was designed to investigate the effect of hydroalcoholic extract and essential oil of heracleum persicum (apiaceae) on lipid profile of male hyperlipidemic rabbits. materials and methods: thirty rabbits were randomly divided into six groups of five each. one group received normal diet and the other groups fed with a high cholesterol (2% w/w) diet for 7 weeks. vehicle, hydr...

phytochemicals are good sources of natural antioxidants and have beneficial effects on human health. many of phenolic phytochemicals have shown antimicrobial and antifungal activity. anise hyssop ( agastache foeniculum [pursh] kuntze ) is a perennial aromatic plant of the lamiaceae family with antimicrobial and antifungal properties and useful for gastrointestinal problems. in this investigatio...

When considering non-central imaging devices, the computation of the relative pose requires the estimation of the rotation and translation that transform the 3D lines from one coordinate system to the second. In most of the state-ofthe-art methods, this transformation is estimated by the computing a 6× 6 matrix, known as the Generalized Essential Matrix. To allow a better understanding of this ...

It has been recently discovered that new genes can originate de novo from noncoding DNA, and several biological traits including expression or sequence composition form a continuum from noncoding sequences to conserved genes. In this article, using yeast genes I test whether the integration of new genes into cellular networks and their structural maturation shows such a continuum by analyzing t...