The serious limitations of the estimating glomerular filtration rate (eGFR) appear related not to a shortcoming of the equation, but to the futility of trying to force agreement between two inherently different parameters: a blood marker of kidney function with a very stable concentration (creatinine) and a renal filtration parameter that fluctuates continually (glomerular filtration rate, GFR)...

Sir, In their article in Nephrology Dialysis Transplantation w1x, discussing the pathophysiology of acute renal failure in the nephrotic syndrome, Koomans et al. (p. 223) mention that obliteration of epithelial slit pores, as visualized by electron microscopy, is not correlated with the reduction in glomer-ular ®ltration rate (GFR) in humans. However, in a previous

The ability of the Modification of Renal Disease (MDRD) equation to predict GFR when compared with multiple other prediction equations in healthy subjects without known kidney disease was analyzed. Between May 1995 and December 2001, a total of 117 healthy individuals underwent (125)I-iothalamate or (99m)Tc-diethylenetriamine-pentaacetic acid (DTPA) renal studies as part of a routine kidney don...

Serum creatinine is measured more than 280 million times annually in the United States, and more than 80% of clinical laboratories now report an estimated glomerular filtration rate (GFR) when serum creatinine is measured.1,2 The most commonly used equation is the Modification of Diet and Renal Disease (MDRD) Study equation. Recently, the Chronic Kidney Disease Epidemiology Collaboration (CKD-E...

BACKGROUND Various estimating equations have been developed to estimate glomerular filtration rate (GFR) for use in clinical practice. However, the unique renal physiological and pathological processes that occur in sickle cell disease (SCD) may invalidate these estimates in this patient population. This study aims to compare GFR estimated using common existing GFR predictive equations to actua...