Introduction Natural and synthetic estrogens are pollutants found in aquatic ecosystems at low concentrations reaching ng.L -1 to μg.L . At these concentrations, they able interfere with the fish endocrine system. When waterborne exposure occurs early life stages, when blood low, this may have significant consequences for estrogen-sensitive functions such as skeletal development. Methods To bet...

Gastrointestinal (GI) epithelial ion transport is physiologically important in many aspects of humans, such as in maintaining fluid balance of whole body, and also plays a role in the development and progression of common GI disease. Estrogen and estrogen receptors have been shown to modulate the activity of epithelial ion secretion in GI tract. This review aims to address the current state of ...

Introduction: The role of estrogen in the stimulation of gonadotropin-releasing hormone (GnRH) neurons is clear. These neurons do not express estrogen alpha receptors, so other mediator neurons should be present to transmit the positive feedback effect of estrogen to the GnRH neurons. Kisspeptin neurons have an important role in the stimulation of GnRH neurons, so they can be the mediator of...

There are two estrogen receptors (ERs), ER and ER , which are ligand activated transcription factors. Estrogen, which exerts its effect via ERs, is not only a female reproductive hormone, but acts almost ubiquitously in the human body and is involved in physiological and pathological states in both males and females. Estrogen has effects in bone maintenance and the cardiovascular and central ne...

Estrogen mediates its effects through multiple cellular receptors. In addition to the classical nuclear estrogen receptors (ERalpha and ERbeta), estrogen also signals through the seven-transmembrane G-protein-coupled receptor (GPCR) GPR30. Although estrogen is a cell-permeable ligand, it is often assumed that all GPCRs function solely as cell surface receptors. Our previous results showed that ...

It has been suggested that the degradation of the articular cartilage and osteoarthritis (OA) are associated with gender and the estrogen hormone. Although many investigators have reported the presence of the estrogen receptors (ERs) alpha and beta in the articular cartilage, the localization of these receptors and the difference in their in vivo expression have not yet been clearly demonstrate...