The immune microenvironment is considered a major obstacle to generating an effective antitumor immune response. Checkpoint inhibitors manipulate the co-stimulatory response between antigen-presenting cells and immune cells-or between the tumor and immune cells-to elicit an antitumor immune response that would have otherwise been suppressed. Checkpoint inhibitors have shown great promise in the...

background : chronic nature of thalassemia causes changes in different aspects of life in patients, including their quality of life. because of the important role of family in caring for children with thalassemia, this study was done to evaluate the effect of family-centered empowerment model on quality of life of the children aged 6-12 years with thalassemia in kerman thalassemia center. metho...

Until recently, computer security was an obscure discipline that seemed to have little relevance to everyday life. With the rapid growth of the Internet, e-commerce, and the widespread use of computers, computer security touches almost all aspects of daily life and all parts of society. Even those who do not use computers have information about them stored on computers. This paper reviews some ...

an important feature of the holy quran, which has often gone unnoticed, is its rich vocabulary and expressions employed to eloquently express various aspects of daily life. this aspect of the holy quran is often reflected in everyday conversations of people from various walks of life: the old and the young, the rich and the poor, the literate and the illiterate, the master and the peasant. this...