Multi-responsive amphiphilic gold nanoparticles (AuNPs) protected by graft poly(ether amine) have been prepared simply by a one-pot photochemical synthesis in the presence of thio-graft poly(ether amine) (gPEA-SH) and the mechanism was studied in detail.

Mechanical point-chirality in a [2]rotaxane is utilized for asymmetric catalysis. Stable enantiomers of the rotaxane result from a bulky group in the middle of the thread preventing a benzylic amide macrocycle shuttling between different sides of a prochiral center, creating point chirality in the vicinity of a secondary amine group. The resulting mechanochirogenesis delivers enantioselective o...

The semicarbazide-sensitive amine oxidases constitute a group of copper-containing enzymes whose physiological function is unclear. The enzymes are present in various tissues, including blood plasma. At present, the source of the plasma enzyme in humans is not known. Results of a recent study suggested that semicarbazide-sensitive amine oxidase is expressed in the skeleton, e.g. in the spine. U...

The aim of this study was to measure the postprandial changes in amino acid and biogenic amine profiles in individuals with impaired fasting glucose (IFG) and to investigate the changes of postprandial amino acid and biogenic amine profiles after a meal of highland barley (HB). Firstly, 50 IFG and 50 healthy individuals were recruited for the measurement of 2 h postprandial changes of amino aci...

The localization of labeled amine in the heart of the bat after administration of tritiated norepinephrine (NE) was studied by means of electron microscope autoradiography. Monoamine oxidase was inhibited so that the distribution of amine in both neuronal (Uptake(1)) and extraneuronal (Uptake(2)) sites could be analyzed. Labeling was nonrandom in both the atrial and ventricular myocardium. The ...

Biocatalytic acylation/amidation is well-known and has been applied for decades but it has often been limited to the use of organic solvents to avoid hydrolysis. The acyl transferase from Mycobacterium smegmatis (MsAcT) is an enzyme that can perform trans-acylations in aqueous solution. Only a few hydrolases can catalyze trans-acylation in water and MsAcT also has the ability to act as a perhyd...

Abstract The synthesis and structural characterization of N -(6-methoxypyridin-3-yl)-4-(pyridin-2-yl)thiazol-2-amine mono-hydrobromide monohydrate ( 3 ) -(6-methoxypyridin-3-yl)-4-(pyrazin-2-yl)thiazol-2-amine 0.35 methanol solvate 4 are reported. crystal structures (monoclinic, space group P 2 1 / n , Z = 4) group, C 2/ c 8) feature ,4-diheteroaryl 2-aminothiazoles showing similar molecular co...

An efficient and facile synthetic procedure has been developed for the synthesis of novel series Bis-6-aryl-imidazo[1,2-a]pyridine-2-carboxamide containing 3,3'-((oxybis(ethane-2,1-diyl))bis(oxy))bis(propan-1-amine) derivatives (6a-6j). application Palladium catalyzed Suzuki reaction on amine-(CH2)3-PEG3-(CH2)3-amine linked 6-bromo imidazo[1,2-a]pyridine-2-carboxamide was reported their product...