In the mol-ecule of pinnatane A, C(30)H(48)O(3), isolated from the bark of Walsura pinnata Hassk, the four cyclo-hexane rings adopt chair conformations; the carboxyl and hydr-oxy substituents occupy axial positions. The cyclo-hexene ring is envelope-shaped. Adjacent mol-ecules are linked by O-H⋯O hydrogen bonds into a chain running along the c axis.

In the title mol-ecule, C(25)H(30)O(4), the two cyclo-hexene rings adopt envelope conformations. The two hy-droxy groups are involved in the formation of intra-molecular O-H⋯O hydrogen bonds. In the crystal structure, weak inter-molecular C-H⋯O hydrogen bonds link mol-ecules related by translation along the axis a into chains.

We perform molecular simulations to study the self-assembly of block copolymer tethered cubic nanoparticles. Minimal models of the tethered nanoscale building blocks (NBBs) are utilized to explore the structures arising from self-assembly. We demonstrate that attaching a rigid nanocube to a diblock copolymer affects the typical equilibrium morphologies exhibited by the pure copolymer. Lamellar ...

Drug Delivery In article number 2000069, Boaz Mizrahi and co-workers report a new nano delivery system that is based on injectable liquid copolymer. The copolymer, starPEG-PLGA (red blue in the image) mixed with drug (green spheres without any solvents or excipients. After mixture injected into body, copolymer self-assembles situ well-defined nanoparticles.

INTRODUCTION Acrylic resins containing acrylic acid (AA), methyl methacrylate (MMA) or acrylic–methacrylic copolymer are the most commonly used polymeric materials for biomedical and pharmaceutical applications owing to their hydrophilicity and biocompatibility.1–4 Recently, a new polyvinyl alcohol (PVA) copolymer designed by copolymerizing AA and MMA with PVA was successfully developed as a ca...

This paper describes the use of immobilized palladium catalysts on Fe3O4 magnetic nanoparticles (MNPs) to afford magnetically separable in methoxycarbonylation 1-hexene. Immobilization homogeneous complex [Pd(L1)Cl2] (Pd1), where L1 = N,N′E,N,N′E)-N,N′-(3-(3-(triethoxysilyl)propyl)pentane-2,4-diylidene)dianiline, MNPs at 100 °C and Pd loading 10% (based wt% Pd1) afforded corresponding [Pd1@Fe3O...

Bletilla striata polysaccharides (BSPs) have been used in pharmaceutical and biomedical industry, the aim of the present study was to explore a BSPs amphiphilic derivative to overcome its application limit as poorly water-soluble drug carriers due to water-soluble polymers. Stearic acid (SA) was selected as a hydrophobic block to modify B. striata polysaccharides (SA-BSPs). Docetaxel (DTX)-load...

This study demonstrates the selective tumor targeting and the antitumor efficacy of the N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-bound mesochlorin e6 monoethylenediamine (Mce6) and HPMA copolymer-bound Adriamycin (ADR) in combination photodynamic therapy (PDT) and chemotherapy against human ovarian OVCAR-3 carcinoma xenografted in female athynmic mice. The concentrations of Mce6 and A...