The need for development of comprehensive therapeutic systems, (e.g., polymer-apatite composites) as a bone substitute material has previously been highlighted in many scientific reports. The aim of this study was to develop a new multifunctional composite based on hydroxyapatite porous granules doped with selenite ions (SeO₃2-) and a biodegradable branched copolymer-bisphosphonate conjugate as...

Slowly degradable copolymers of L-lactide and ε-caprolactone can provide long-term delivery and may be interesting as alternative release systems of cyclosporine A (CyA) and rapamycin (sirolimus), in which available dosage forms cause a lot of side effects. The aim of this study was to obtain slowly degradable matrices containing immunosuppressive drug from PLACL initiated by nontoxic Zr[Acac]₄...

The solubilization of hydrocarbons by micelles formed of diblock and symmetric triblock copolymers in water are compared in the framework of a mean-field theory of solubilization. The block copolymers contain poly(ethylene oxide) as the hydrophilic block and poly(propylene oxide) as the hydrophobic block and are designated as EXPYEX or EWPZ (where E and P denote ethylene and propylene oxides an...

New ytterbium (III) compounds with β-diketones (2,7-dimethyl-octene-1-dione-3,5 and 2,6-dimethylheptene-1-dione-3,5) their derivatives phenanthroline have been synthesized. The composition chemical structure of the obtained complexes determined by several Phy­sico-chemical investigations. It has shown, that Yb ion coordinates three ligand molecules coordination sphere is supplemented two mole­c...

Solubilization and encapsulation of fullerenes C60 and C70 by ultralarge hollow micelles formed by rod-coil diblock copolymers and characterization of the resulting self-organized fullerene-block copolymer assemblies are reported. The solubilization capacity of each fullerene in poly(phenylquinoline)-blockpolystyrene (PPQ-PS) micelles in binary solvents, trifluoroacetic acid/dichloromethane, an...

Phase separation of asymmetric diblock copolymer near surfaces in selective solvents is theoretically investigated by using the real-space version of self-consistent field theory (SCFT). Several morphologies are predicted and the phase diagram is constructed by varying the distance between two parallel hard surfaces (or the film thickness) W and the block copolymer concentration f(P). Morpholog...

To improve the release profile of peptide drugs, thermos-responsive triblock copolymer poly (ε-caprolactone-co-p-dioxanone)-b-poly (ethylene glycol)-b-poly (ε-caprolactone-co-p-dioxanone) (PECP) was prepared and end capped by succinic anhydride to give its carboxylic terminated derivative. Both PCEP block copolymer and its end group modified derivative showed temperature-dependent reversible so...

Poorly soluble drugs have low bioavailability after oral administration, thereby hindering effective drug delivery. A novel drug-delivery system of docetaxel (DTX)-based stearic acid (SA)-modified Bletilla striata polysaccharides (BSPs) copolymers was successfully developed. Particle size, zeta potential, encapsulation efficiency (EE), and loading capacity (LC) were determined. The DTX release ...

Electrospun polycaprolacyone/polymethacrylic acid graft copolymer nanofibers (PCL/MAA) containing silver nanoparticles (AgNPs) were synthesized for effective wound disinfection. Surface morphology, AgNPs content, water uptake of electrospun PCL/MAA graft copolymer nanofibers without and with AgNPs, and levels of AgNPs leaching from the nanofibers in water as well as antimicrobial efficacy were ...

Homopolymer and block copolymer bearing carbohydrate side chain functionality were obtained by grafting glucothiose onto alkene functional scaffolds via a thiol-ene click reaction and the resulting copolymer was used to form thermo-responsive micelles as a potential drug carrier.