Here we report two novel 17-mer amidated linear peptides (TsAP-1 and TsAP-2) whose structures were deduced from cDNAs cloned from a venom-derived cDNA library of the Brazilian yellow scorpion, Tityus serrulatus. Both mature peptides were structurally-characterised following their location in chromatographic fractions of venom and synthetic replicates of each were subjected to a range of biologi...

Recently it has been established that y toxin of Tityus serrulatus scorpion venom has a very high affinity to Na channels and can be successfully used as a marker during their purification from excitable membranes (Barhanin et al. 1983 ; Grishin 1983). There has, however, been some controversy concerning the effects of the y toxin on properties of Na channels in different tissues. Thus, in neur...