OBJECTIVES Normoglycemic Wistar rats' Glycated Hemoglobin Levels (GHL) showed a time-dependent difference between control groups and those exposed to regular inhalation of peroxidizing extracts of turpentine. These extracts were able to optimize the oxygen permeation at the cellular level during and subsequently to a breathing session. The more the rats breathed turpentine peroxidized vapor, th...

The prediction of the in vivo performance self-nanoemulsifying drug delivery systems (SNEDDSs) is currently gaining increasing attention. Therefore, need for reliable vitro models able to assess solubilization capacity such formulations upon lipolysis, as well concomitantly evaluate permeation, has become ever so evident. In current study, high-throughput intestinal lipolysis model was combined...

Methotrexate on its oral and intravenous administration results in unwanted adverse effects. This drawback can be overcome by transdermal delivery because of painless objective for systemic drug administration. Transfersomes are ultra-deformable vesicles with the flexibility to reach deeper tissues skin. The this research work was develop methotrexate transfersomal gel thin film hydration techn...

In the present study, luteolin (LTN)-encapsulated chitosan (CS) coated nanostructured lipid carriers (NLCs) were formulated using melt emulsification ultrasonication technique. NLCs optimized by 33-QbD approach for improved in vitro efficacy against breast cancer cell lines. The LTN-CS-NLCs successfully characterized different and ex vivo experiments as well evaluated cytotoxicity MDA-MB-231 MC...

Background: Natamycin belongs to a large group of naturally occurring polyene antifungal antibiotics derived from Streptomyces natalensis. has restrictive pharmaceutical role because its extremely low aqueous solubility, which severely reduces the bioavailability drug. To improve absorption drug, nanocrystals natamycin were prepared and incorporated into in situ gel.
 Aim: solubility by pr...

The aim of this work was to develop a new in vitro lipolysis-permeation model predict the vivo absorption fenofibrate self-nanoemulsifying drug delivery systems (SNEDDSs). More specifically, intestinal lipolysis combined with mucus-PVPA (Phospholipid Vesicle-based Permeation Assay) permeability model. Biosimilar mucus (BM) added surface PVPA barriers closer simulate mucosa. SNEDDSs for which ph...

The present study deals with formulation and evaluation of flexible liposome embedded thermoreversible in situ intranasal gel rizatriptan benzoate. liposomes were formulated (F1-F9) optimized respect to percentage ethanol phospholipid get optimum vesicle size entrapment efficiency. vesicles characterized for their size, shape zeta potential. stable incorporated into gel. ex vivo permeation drug...

OBJECTIVE To investigate the ability of α-tocopherol acetate (TA) and α-tocopherol (T), widely used ingredients in cosmetics, to cross the epidermal barrier using the neonatal rat as a model. MATERIALS AND METHODS The content of T and TA in four marketed products (A-D) and two experimental formulations (F1, F2) was investigated by HPLC. An in vitro permeation study was performed in neonatal r...