The purpose was to investigate the in vivo skin penetration of four 14C-salicylic compounds using microdialysis and to relate dermal concentrations to structural features. Furthermore, to compare two in vivo retrodialysis recovery methods for estimation of true unbound extracellular concentrations. Microdialysis probes were inserted in the dermis of hairless rats. Equimolal 14C-salicylic formul...

Background Non-enzymatic hydroxylation of aromatic compounds to the respective phenolic derivatives is a possible metabolic pathway of xenobiotics. The formed metabolites can undergo consecutive oxidative reactions with free radicals to form potential toxic molecules. Objective Development of HPLC methods to separate, identify and quantitate the main products formed from salicylic acid, 2,3-d...

Root colonization by specific nonpathogenic bacteria can induce a systemic resistance in plants to pathogen infections. In bean, this kind of systemic resistance can be induced by the rhizobacterium Pseudomonas aeruginosa 7NSK2 and depends on the production of salicylic acid by this strain. In a model with plants grown in perlite we demonstrated that Pseudomonas aeruginosa 7NSK2-induced resista...

8 9 1. Detailed experimental procedures for OH determination: 10 In this study, the measurements of salicylic acid degradation were both separately done 11 from the DHAA degradation experiments and concurrently with the DHAA measurements. 12 The OH concentration were calculated through the determination of the products of salicylic 13 acid-OH reaction (2,3-dihydroxybenzonic acid and 2,5-dihydro...

As part of a proactive approach to environmental protection, emerging issues with potential impact on the environment is the subject of ongoing investigation. One emerging area of environmental research concerns pharmaceuticals like salicylic acid, which is the main metabolite of various analgesics including aspirin. It is a common component of sewage effluent and also an intermediate in the de...

The present investigation has evaluated the influence of aspirin, its constituents, and other nonsteroidal anti-inflammatory agents on the resistance of human platelets to aspiration into micropipettes. Aspirin increased the length of platelet extensions into the micropipette over the entire negative tension range of 0.04 to 0.40 dynes/cm after exposure to the drug in vitro or after ingestion o...

The salinity of the soil and irrigation water is one great challenges agriculture. Salinity can have harmful effects on physiological processes plant growth, including Tropaeolum majus L. (Tropaeolaceae). application phytohormones be a strategy to mitigate these effects. aim this study was evaluate jasmonic acid, salicylic cytokinin polyamine as attenuators salt stress in T. majus. Three levels...

INTRODUCTION Pulsed dye laser (PDL) has been used to treat acne lesions and scar erythema by interrupting superficial vasculature. Salicylic acid chemical peels are employed chiefly due to their lipophilic, comedolytic, and anti-inflammatory properties. Although studies have looked at peels and laser therapy independently in acne management, we examined these treatments in combination. Our prim...

BACKGROUND While oral tacrolimus is effective for the treatment of psoriasis, tacrolimus ointment has shown only spotty efficacy in the treatment of plaque psoriasis. The efficacy of tacrolimus ointment for the treatment of facial and intertriginous psoriasis suggests that if tacrolimus penetration can be increased, the ointment could be used for effective treatment of plaque psoriasis. OBJEC...

recently, application of sa has increased to improve plants resistance to stresses such as drought. hence, to investigate sa effects on morphophysiological characteristics of fennel(foeniculum vulgare mill.) under drought stress, a split plot experiment based on latin square design with three replications was carried out at research farm of shahid bahonar university of kerman in 2012. three lev...