نتایج جستجو برای: exosome activity

تعداد نتایج: 1137073  

2017
Sergey E. Sedykh Lada V. Purvinish Artem S. Monogarov Evgeniya E. Burkova Alina E. Grigor'eva Dmitrii V. Bulgakov Pavel S. Dmitrenok Valentin V. Vlassov Elena I. Ryabchikova Georgy A. Nevinsky

Exosomes are 40-100 nm nanovesicles containing RNA and different proteins. Exosomes containing proteins, lipids, mRNAs, and microRNAs are important in intracellular communication and immune function. Exosomes from different sources are usually obtained by combination of centrifugation and ultracentrifugation and according to published data can contain from a few dozens to thousands of different...

Journal: :American journal of physiology. Renal physiology 2013
Lin-Li Lv Yu-Han Cao Hai-Feng Ni Min Xu Dan Liu Hong Liu Ping-Sheng Chen Bi-Cheng Liu

Micro (mi)RNAs are frequently dysregulated in the development of renal fibrosis. Exosomes are small membrane vesicles that could be isolated from urine secreted from all nephron segments. Here we sought to observe for the first time whether miRNA in urine exosome could serve as a potential biomarker of renal fibrosis. Urine samples were collected from 32 chronic kidney disease (CKD) patients wh...

Journal: :Acta crystallographica. Section D, Biological crystallography 2004
Jozef Sevcík Zbigniew Dauter Keith S Wilson

Three different strains of Streptomyces aureofaciens produce the homologous ribonucleases Sa, Sa2 and Sa3. The crystal structures of ribonuclease Sa (RNase Sa) and its complexes with mononucleotides have previously been reported at high resolution. Here, the structures of two crystal forms (I and II) of ribonuclease Sa2 (RNase Sa2) are presented at 1.8 and 1.5 A resolution. The structures were ...

Journal: :The EMBO journal 2000
A van Hoof P Lennertz R Parker

The biogenesis of a number of RNA species in eukaryotic cells requires 3' processing. To determine the enzymes responsible for these trimming events, we created yeast strains lacking specific 3' to 5' exonucleases. In this work, we describe the analysis of three members of the RNase D family of exonucleases (Rex1p, Rex2p and Rex3p). This work led to three important conclusions. First, each of t...

Journal: :Cell 2006
Vincent Shen Megerditch Kiledjian

The exosome is a 3' to 5' exoribonuclease central to many cellular processes, including mRNA decay. now present the biochemical reconstitution and crystal structure of the eukaryotic exosome. This remarkable achievement provides key insights into the composition and assembly of the human and yeast exosomes, revealing functions of individual subunits.

2018
Ting Shen Qing-Qing Zheng Jiang Shen Qiu-Shi Li Xing-Hui Song Hong-Bo Luo Chao-Yang Hong Ke Yao

Background Corneal stromal cells (CSCs) are components of the corneal endothelial microenvironment that can be induced to form a functional tissue-engineered corneal endothelium. Adipose-derived mesenchymal stem cells (ADSCs) have been reported as an important component of regenerative medicine and cell therapy for corneal stromal damage. We have demonstrated that the treatment with ADSCs leads...

Journal: :The Journal of biological chemistry 2009
Isabella Parolini Cristina Federici Carla Raggi Luana Lugini Simonetta Palleschi Angelo De Milito Carolina Coscia Elisabetta Iessi Mariantonia Logozzi Agnese Molinari Marisa Colone Massimo Tatti Massimo Sargiacomo Stefano Fais

Exosomes secreted by normal and cancer cells carry and deliver a variety of molecules. To date, mechanisms referring to tumor exosome trafficking, including release and cell-cell transmission, have not been described. To gain insight into this, exosomes purified from metastatic melanoma cell medium were labeled with a lipid fluorescent probe, R18, and analyzed by spectrofluorometry and confocal...

Journal: :Annals of urologic oncology 2023

Bladder cancer (Bca) is one of the most common tumors in urinary system. Cystoscopy biopsy a gold standard for diagnosis Bca clinic. However, cystoscopy invasive, costly and invasive process causing pain patients. Because cells are closely contact with urine, exosomes can pass through base membrane transport microRNA (miRNAs) to so detection exosome-derived miRNAs urine expected be new non-inva...

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