BACKGROUND Abnormalities in normal-appearing brain tissues may contribute to disability in primary progressive multiple sclerosis (PPMS), where few lesions are seen on conventional imaging. OBJECTIVES To evaluate the mechanisms underlying disease progression in the early phase of PPMS by measuring metabolite concentrations in normal-appearing white matter (NAWM) and cortical gray matter (CGM)...

background: multiple sclerosis (ms) is an inflammatory and demyelinating disease of central nervous system (cns). the aim of the present study was to determine the type and the frequency of initial presenting symptoms in patients with ms and their relation with demographic characteristics in babol, northern iran. methods: all patients of this study were recruited over a ten year period from 200...

OBJECTIVES Bowel and bladder symptoms are highly prevalent in patients with multiple sclerosis (MS). Bladder dysfunction (affecting 75% of these patients) is caused by disease in the spinal cord, whilst the pathophysiology of bowel dysfunction is unknown. Pathways regulating both the organs lie in close proximity to the spinal cord, and coexistence of their dysfunction might be the result of a ...

BACKGROUND/AIM Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system. The main physiopatological feature of MS is demyelination. Multiple sclerosis is one of three most common causes of severe disability in youngest people. In patients with MS, apart from complete psychophysical status and objective neurologic status, a subjective perception of symptoms and signs, ...

Multiple Sclerosisis (MS) is a common demylinating disease of CNS that inflammation and stress oxidative processes have an important role in clinical courses and progression of it. Suppressing the antigen-presenting capacity of glial cells seems a convinient way of reducing inflammatory activity in MS. The aim of the present study was to determine the anti-inflamatory effects of Melatonin on fa...

Background: Multiple Sclerosis (MS) is a demyelinating disorder of the central nervous system. Tremors are a common problem in the patients suffering from MS which is mostly observed in the arms but can also affect the other body parts. There have been few studies on tremors among the MS patients.  Objectives: This study is the first to report the prevalence of tremor in a group of MS pat...

Abstract Background The role of adipokines such as leptin and adiponectin in regulating the immunity has been documented, however data concerning their consequence on multiple sclerosis (MS) Egyptian patients are deficient. aim this study is to demonstrate serum levels MS assess association with disease disability severity. A case–control including 60 subjects (30 30 age, sex body mass index-ma...

multiple sclerosis (ms) is a demyelinating disease of the central nervous system, with unknown etiology in which both genetic and environmental factors are thought to be involved. the human leukocyte antigen (hla) system provides a set of genetic markers which lend themselves to systematic study. in iran, hla-a24, hla-dr2, and hla- dr15 are significantly increased in ms patients. the disease al...