Hyperspectral imagery is a new type of high-dimensional image data which is now used in many Earth-based and planetary exploration applications. Many efforts have been devoted to designing and developing compression algorithms for hyperspectral imagery. Unfortunately, most available approaches have largely overlooked the impact of mixed pixels and subpixel targets, which can be accurately model...

Targeted therapeutics such as monoclonal antibodies (mAbs) have proven successful as cancer drugs. To profile products that could be marketed in the future, we examined the current commercial clinical pipeline of mAb candidates for cancer. Our analysis revealed trends toward development of a variety of noncanonical mAbs, including antibody-drug conjugates (ADCs), bispecific antibodies, engineer...

Visual exploration is an omnipresent activity in everyday life, and might represent an important determinant of visual attention deficits in patients with Alzheimer's Disease (AD). The present study aimed at investigating visual search performance in AD patients, in particular target detection in the far periphery, in daily living scenes. Eighteen AD patients and 20 healthy controls participate...

Identification of genes that affect the product accumulation phenotype of recombinant strains is an important problem in industrial strain construction and a central tenet of metabolic engineering. We have used systematic (model-based) and combinatorial (transposon-based) methods to identify gene knockout targets that increase lycopene biosynthesis in strains of Escherichia coli. We show that t...

We present the research and development status of two MPEG-7 indexing/search systems under development at the Computer Research Institute of Montreal (CRIM). The first (called ERIC-7) targets content-based encoding of still images and is mainly designed to experiment with the various aspects of the visual MPEG-7/XML schema with the help of analysis and exploration tools. The interface allows na...

Gene regulation relies on transcription factors (TFs) exploring the nucleus searching their targets. So far, most studies have focused on how fast TFs diffuse, underestimating the role of nuclear architecture. We implemented a single-molecule tracking assay to determine TFs dynamics. We found that c-Myc is a global explorer of the nucleus. In contrast, the positive transcription elongation fact...

As an effective active remote sensing technology for the exploration of shallow underground targets, ground-penetrating radar (GPR) is a detection method that can be used to obtain information about characteristics targets by transmitting electromagnetic wave from antenna and analyzing propagation underground. Due frequency (1 MHz–3 GHz) GPRs, depth geological (0.1–30 m). In order penetrate dee...

HOUSTON–Technology advances such as wide-azimuth/full-azimuth (WAZ/FAZ) acquisition, reverse-time migration (RTM) and iterative salt imaging in model building have greatly improved subsalt image quality. In the Gulf of Mexico, steeply dipping three-way closures are familiar subsalt targets. However, despite these imaging improvements, some of these targets remain poorly imaged. The fundamental ...