www.pacb.com/denovo In the days of Sanger sequencing, organisms considered most scientifically important were targeted for high-quality, finished genomes. There was no question that this was an expensive and laborious goal, but it was widely accepted that a finished genome answered questions that no draft assembly ever could. As short-read sequencing technologies became available, they were emb...

OBJECTIVE We estimated the investment needs, population health gains, and cost-effectiveness of different policy options for scaling-up prevention and treatment of HIV in the 10 countries that currently comprise 80% of all people living with HIV in sub-Saharan Africa (Ethiopia, Kenya, Malawi, Mozambique, Nigeria, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe). DESIGN We adapted the est...

BACKGROUND This paper is part of a project to identify the proportion of the burden of each mental disorder averted by current and optimal interventions, and the cost-effectiveness of both. AIMS To use epidemiological data on schizophrenia to model the cost-effectiveness of current and optimal treatment. METHOD Calculate the burden of schizophrenia in the years lived with disability (YLD) c...

Evaluation of: Pareek M, Watson JP, Ormerod LP et al. Screening of immigrants in the UK for imported latent tuberculosis: a multicentre cohort study and cost-effectiveness analysis. Lancet Infect. Dis. 11(6), 435-444 (2011).Tuberculosis (TB) is a serious public health problem in the UK, and detection and prophylactic treatment of latent infection offers improved control. A recent study advocate...

BACKGROUND Continuous-loop event recorders are widely used for the evaluation of palpitations, but the optimal duration of monitoring is unknown. OBJECTIVE To determine the yield, timing, and incremental cost-effectiveness of each week of event monitoring for palpitations. DESIGN Prospective cohort study. PATIENTS 105 consecutive outpatients referred for the placement of a continuous-loop...

This paper argues that the National Institute for Health and Clinical Excellence should not offer guidance in situations where there is insufficient evidence equipoise about the potential benefit of the treatment in question. This is broadly for two reasons. First, without knowing if the treatment is effective no cost-effectiveness judgement can be logically made. Second, the implementation of ...

This article is motivated by a concern for the cost-effectiveness of anti-poverty outlays; much of its focus is on the targeting of Rural Public Works (RPW) and the Integrated Rural Development Programme (IRDP) over the period 1987±93. It is argued that benefits to the rural poor of larger outlays on these two major anti-poverty programmes are likely to be limited, given their mistargeting. Lar...

OBJECTIVE We estimated the cost effectiveness of the Oregon tobacco quitline's "free patch initiative" compared to the pre-initiative programme. METHODS Using quitline utilisation and cost data from the state, intervention providers and patients, we estimated annual programme use and costs for media promotions and intervention services. We also estimated annual quitline registration calls and...

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OBJECTIVE To determine the cost-effectiveness of averting the burden of disease. We used secondary population data and metaanalyses of various government-funded services and interventions to investigate the costs and benefits of various levels of treatment for rheumatoid arthritis (RA) and osteoarthritis (OA) in adults using a burden of disease framework. METHOD Population burden was calculat...