Using a rabbit sterile peritonitis model, we compared the penetration of intravenously administered amikacin, gentamicin, and penicillin G into peritoneal exudate. Peritonitis was induced with sterile normal saline, and the peritoneal exudate contained 23,751 +/- 3,039 granulocytes 8 h later. Antibiotics were administered intravenously 3 h after initiating peritonitis, and serum and peritoneal ...

Slough covering the surface of a wound is formed of dead tissue, fibrin, fibrinogen and proteins that may have contributed to the healing process (Gray et al, 2010). It can adhere to the wound surface and be difficult to remove. Slough can act as a growth medium for bacteria, inhibit angiogenesis, extra cellular matrix formation and the progression of keratinocytes across the surface of a wound...

The chemotactic response of Bradyrhizobium japonicum toward soybean seed and root exudates was examined. Assays using various isoflavones and fractionated exudate indicated that isoflavones are not the principal attractants in exudates. Likewise, induction of nod genes with isoflavones or seed exudate before assay did not enhance chemotaxis. Screening of numerous compounds revealed that only di...

Coincident with the marked macrophage reaction induced in the peritoneal cavity by oil injection, there is an increased resistance of this location to bacterial infections. Animals so prepared dispose of Bacillus coli in a much shorter time than normal animals, and survive multiples of the fatal doses of staphylococci and pneumococi. The amount of oil injected is in itself incapable of inhibiti...

Fronds o f the neotropical fern Pityrogramma trifoliata produce a farinose exudate which consists mainly o f a dihydrochalcone. The structure o f som e minor constituents has been elucidated by spectroscopic methods. They are shown to be representatives o f a novel class o f complex flavonoids, composed o f a flavonoid and a neoflavonoid moiety. In other terms, they are 5,7-dihydroxy-8-cinnamoy...

The World Health Organization document (WHO, 2010), Wound and Lymphoedema Management, stresses the need to integrate lymphoedema, chronic oedema and wound care (Bolton, 2010). Due to skin changes that occur in patients with chronic oedema, there is the potential for venous ulceration to occur (Hampton, 2010). Thus, dressings are required to manage infection and exudate. Conditions such as lymph...

The pharmacokinetics and penetration into a cantharidine-induced inflammatory exudate of meropenem was studied in six volunteers following a single 1-g intravenous dose. Concentrations in plasma, urine, and the inflammatory exudate were determined by a microbiological assay. The mean elimination half-life of meropenem in plasma was 1.1 h, with the concentration in plasma declining from a mean o...

Chyliform pleural effusions are a little known occurrence only sparingly reported in the literature. At the lung department in Uppsala, Sweden, 11 cases have been seen the last few years. Typically, the exudate develops in a long-standing pleural thickening resulting from therapeutic pneumothorax many years earlier. The exudate contains a high level of cholesterol, probably breakdown products f...