Introduction: Tumor-infiltrating regulatory T cells (Tregs) contribute to an immunosuppressive tumor microenvironment. Despite extensive studies, the prognostic impact of infiltrating Tregs in non-Hodgkin lymphomas (NHL) remains unclear. Emerging studies suggest substantial heterogeneity phenotypes and suppressive capacity Tregs, emphasizing importance understanding Treg diversity need for mark...

Introduction One of the great challenges still to be achieved in schizophrenia is development a staging model that reflects progression disorder. The previous models suggested have been developed from theoretical point view and do not include objective variables such as biomarkers, physical comorbidities, or self-reported subjective (Martinez-Cao et al. Transl Psychiatry 2022; 12(1) 1-11). Obje...

Introduction The preliminary examination of Stardust samples has yielded a number of surprising findings, such as the presence of large refractory mineral grains, including materials resembling CAIs, chondrules, and AOA fragments [1-3]. Furthermore, intact organics and fine grained materials are unexpectedly rare in Stardust tracks [4,5]. The fact that intact fine grained materials are uncommon...

Introduction: The aluminum foils wrapped around the sample tray assembly (STA) of the Stardust spacecraft will contain a record of both cometary and interstellar dust hypervelocity collisions in the form of craters [1-2]. While the primary goal of the cratering preliminary examination (PE) is to define the cometary particle flux [2], previous studies of exposed metallic foils in space have show...

New treatment approaches are needed for patients with severe and composite mental disorders who are resistant to conventional treatments. Such treatment-resistant patients often have diagnoses of psychotic or bipolar disorders or severe personality disorders and comorbid conditions. In this study, we evaluate basal exposure therapy (BET), a novel ward-integrated psychotherapeutic approach for t...

BACKGROUND A quarter of people with psychotic conditions experience persistent auditory verbal hallucinations, despite treatment. AVATAR therapy (invented by Julian Leff in 2008) is a new approach in which people who hear voices have a dialogue with a digital representation (avatar) of their presumed persecutor, voiced by the therapist so that the avatar responds by becoming less hostile and co...

BACKGROUND The aim of the study was to determine the costs of treating schizophrenia from the perspective of the statutory health insurance, as well as the identification of predictors of hospitalisation of formerly stable schizophrenia patients. METHODS Claims data for the years 2004-2006 were analysed. Patients who did not have to be treated in a hospital as a result of an ICD diagnosis F20...

An experimental technique to accurately quantify the deformation and the bend-twist coupling of high performance composite foils under fluid loading is presented. The experimental results are reproduced in a Computational Fluid Dynamic (CFD) environment to assess the impact of board deflection and changes in pitch angle on vertical force generated in the C-foils while sailing under increased hy...

In the highly inbred Strong A strain of mice, an attempt to produce divergent sub-strains with regard to age distribution of spontaneous mammary adenocarcinomas by means of selective breeding proved ineffectual.' It was concluded that this result was an exemplification of Johannsen's genetic principle that pure lines are not amenable to selection. Conversely, Kreyberg8 succeeded in selecting di...