We present the case of a 70-year-old woman found to have a prothrombin time (PT) of 26.8 seconds (s) and an activated partial thromboplastin time (PTT) of 71 s prior to an elective endoscopic retrograde cholangiopancreatography for symptomatic choledocholithiasis. She had no personal or family history of bleeding, thrombosis, autoimmune diseases, miscarriages, recent surgery or antibiotic use, ...

A CROSS 1 3 generations and 55 affected members, the “bleeders of Tenna” in eastern Switzerland have demonstrated that hemophilia B is not necessarily severe or associated with spontaneous bleeding episodes.’ Moreover, patients with congenitally deficient factor IX activity are clinically indistinguishable from those with factor VIII deficiency, that is, hemophilia A. Both types of hemophilia a...

Background Hemophilia A and B are disorders resulting from a deficiency in factor VIII (FVIII), and factor IX (FIX), respectively. Tissue Factor (TF) is a key component of the extrinsic pathway and plays a role in the coagulation defect of hemophilic blood. Neutralizing the activity of TFPI represents a promising treatment concept in patients with hereditary or acquired hemophilia. ARC19499 is ...

BACKGROUND Schistosomiasis mansoni is a chronic liver disease, in which some patients (5-10%) progress to the most severe form, hepatosplenic schistosomiasis. This form is associated with portal hypertension and splenomegaly, and often episodes of gastrointestinal bleeding, even with liver function preserved. Splenectomy is a validated procedure to reduce portal hypertension following digestive...

We have investigated the influence of alterations in plasma coagulation factor levels between 50% and 150% of their mean values for prothrombin, factor X, factor XI, factor IX, factor VII, factor VIII, factor V, protein C, protein S, antithrombin III (AT-III), and tissue factor pathway inhibitor (TFPI) as well as combinations of extremes, eg, 50% anticoagulants and 150% procoagulants or 50% pro...

Factor IXa was shown to inactivate both factor Vlll and factor Vllla in a phospholipid-dependent reaction that could be blocked by an antifactor IX antibody. Factor IXa-catalyzed inactivation correlated with proteolytic cleavages within the A1 subunit of factor Vllla and within the heavy chain (contiguous AI-A2-6 domains) of factor VIII. Furthermore, a relatively slow conversion of factor Vlll ...

Hemophilic pseudotumor is a rare complication of hemophilia, occurring in 1 to 2 percent of individuals with severe factor VIII or factor IX deficiency. A 35-year-old male presented with a swelling in the right lower abdomen for 3 months. There was no history of trauma. Examination revealed a swelling over the right iliac fossa. Right hip showed 30° flexion deformity. Blood investigations like ...

Attendances at the Regional Haemophilia Reference Centre in the Edinburgh Royal Infirmary have been analysed over a period of five years from 1969 to 1973. Of 77 patients registered in 1969, 64 had haemophilia A (factor VIII deficiency) and 13 had haemophilia B (factor IX deficiency). In 1973 the numbers were 68 and 14 respectively. An increased attendance at the Centre from 123 in 1969 to 624 ...