wellbore instability is a quite common event during drilling, and causes many problems such as stuck pipe and lost circulation. it is primarily due to the inadequate understanding of the rock properties, pore pressure, and earth stress environment prior to well construction. this study aims to use the existing relevant logs, drilling, and other data from offset wells to construct a precise mech...

S = support of heart afforded by the pericardium T = tone of muscle. The support of the pericardium is due to the negative pressure in the pericardial cavity which I have shown is present in health. This negative pressure causes a suction action which keeps the pericardium right up against the heart save for the thin layer of pericardial fluid so necessary for lubrication. F varies directly wit...

This study proposes a new methodology that combines dynamic process simulation (DPS) and Monte Carlo simulation (MCS) to determine the design pressure of fuel storage tanks on LNG-fueled ships. Because the pressure of such tanks varies with time, DPS is employed to predict the pressure profile. Though equipment failure and subsequent repair affect transient pressure development, it is difficult...

BACKGROUND The utility of single versus combined blood pressure (BP) components in predicting cardiovascular disease (CVD) events is not established. We compared systolic BP (SBP) and diastolic BP (DBP) versus pulse pressure (PP) and mean arterial pressure (MAP) combined and each of these 4 BP components alone in predicting CVD events. METHODS AND RESULTS In participants in the original (n=47...

BACKGROUND The benefits of blood pressure lowering treatment for prevention of cardiovascular disease are well established. However, the extent to which these effects differ by baseline blood pressure, presence of comorbidities, or drug class is less clear. We therefore performed a systematic review and meta-analysis to clarify these differences. METHOD For this systematic review and meta-ana...

Chronic renal failure is a worldwide public health problem, and high-blood pressure is one the most important cause of dame to the kidneys. The incidence and prevalence of renal failure are increasing and are associated with poor consequences and high cost. The activity of the renin-angiotensin system (RAS) plays a central role in the pathogenesis of chronic renal failure, high-blood pressure a...

AIMS In chronic heart failure, proportional pulse pressure (PPP) is suggested as an estimate of cardiac index (CI). The association between CI and PPP in acute heart failure (AHF) has not been described. METHODS This was examined using hemodynamic measurements (from a trial using serelaxin) in 63 stabilized AHF patients. RESULTS Mean (SD) age was 68 (11), 74% male, mean (SD) ejection fracti...

background the transjugular intrahepatic portosystemic stent-shunt (tipss) builds a shortcut between the portal vein and a liver vein, and represents a sophisticated alternative to open surgery in the management of portal hypertension or its complications. objectives to describe clinical experiences with a low-profile nitinol stent system in tipss creation, and to assess primary and long-term s...

Fibroblasts, which are the most numerous cell type in the heart, interact with cardiomyocytes in vitro and affect their function; however, they are considered to play a secondary role in cardiac hypertrophy and failure. Here we have shown that cardiac fibroblasts are essential for the protective and hypertrophic myocardial responses to pressure overload in vivo in mice. Haploinsufficiency of th...

The study of two-phase fluid flow behavior in hydraulic structures such as pressurized flow tunnels, culverts, sewer pipes, junctions and other similar conduits is of great importance. A two-phase mixture flowing in a pipe can exhibit several interfacial geometries such as bubbles, slugs or films, depending on the fluid and hydrodynamic properties of flow. The main variables, giving rise to a v...