P63, a p53 family tumor suppressor, is involved in many cellular processes, including growth suppression and differentiation. Thus, p63 activity needs to be tightly controlled. Here, we found that RNPC1, a RNA-binding protein and a target of the p53 family, regulates p63 mRNA stability and consequently p63 activity. Specifically, we showed that overexpression of RNPC1 decreases, whereas knockdo...

There are stable individual differences in exposure to stressful circumstances over time. The current study employed a latent trait-state model to estimate the magnitude of that stability and its sources. Adults (N = 327; age M = 43.9 years, SD = 6.15) provided reports of hassles and depressive symptoms every three months for two years. A Trait-State-Error model suggested that 60% of the varian...

The paper investigates the concept of software “stability” applied to robot systems. We define “stable” a family of systems modelled, designed and implemented so that specific applications of the family may be developed re-using, adapting and specializing knowledge, architecture and existing components. During the last few years, many ideas and technologies of software engineering (e.g. modular...

This paper uses data from the first four waves of the Fragile Families and Child Wellbeing Study to examine the following questions: (1) what are unmarried parents' capabilities at the time of their child's birth, and what is the nature of their relationship at birth and over time? (2) How do family structure and stability affect parental resources (financial and health)? (3) How do family stru...

An interaction form is an abstract model of interaction based on a description of power distribution among agents over alternatives. A solution known as the settlement set is defined at any preference profile. Necessary and sufficient conditions for stability, that is the existence of settlements, are established. A Stability Index that plays a role similar to that of the Nakamura Number is def...

The recently-proposed family of Forward-andBackward (FAB) Telegraph-Diffusion (TeD) equations [9] is analyzed in the context of image enhancement. Stability of such schemes in terms of energy convergence is investigated. An approximated version of the enhancement operator that offers an increased stability is proposed and examined. This scheme is implemented in both stable and unstable regimes ...

The recently-proposed family of Forward-andBackward (FAB) Telegraph-Diffusion (TeD) equations [9] is analyzed in the context of image enhancement. Stability of such schemes in terms of energy convergence is investigated. An approximated version of the enhancement operator that offers an increased stability is proposed and examined. This scheme is implemented in both stable and unstable regimes ...

In this paper two disturbance decoupling problems without stability and with quadratic stability via dynamic output feedback for switched linear systems are investigated. Firstly, simultaneous (C,A,B)-pair which incorporates both the concept of simultaneous (A,B)-invariant subspace and its dual simultaneous (C,A)-invariant subspace for a family of linear systems are investigated. Secondly, dist...

Protein thermal stability is important for therapeutic proteins, both influencing the pharmacokinetic and pharmacodynamic properties and for stability during production and shelf-life of the final product. In this paper we show the redesign of a therapeutically interesting trimeric all-beta-sheet protein, the cytokine TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), yielding var...