P-glycoprotein (P-gp) is an ATP-dependent transporter localized at the apical membrane of the kidney proximal tubules, which plays a role in the efflux of cationic and amphipathic endogenous waste products and xenobiotics, such as drugs, into urine. Studies in mice deficient in P-gp showed generalized proximal tubular dysfunction similar to the phenotype of patients with cystinosis, an autosoma...

For i.i.d. samples of size n, the ordinary bootstrap (Efron (1979)) is known to be consistent in many situations, but it may fail in important examples (Bickel, Götze and van Zwet (1997)). Using bootstrap samples of size m, where m → ∞ and m/n → 0, typically resolves the problem (Bickel et al. (1997), Politis and Romano (1994)). The choice of m is a key issue. In this paper, we consider an adap...