A simple, fast and cost-effective three-step synthesis of 1-methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione has been developed. The reactions described herein proceed readily, with high yields no further purification. Therefore, the proposed method, an overall yield 60%, offers a facile pathway to N-1 monosubstituted spiro carbocyclic imidazolidine-2,4-diones (hydantoins), which constitute ...

We have developed a Ni-catalyzed cascade cyclization/Negishi-coupling reaction for the formation of pyrrolidines and pyrrolidinones starting from N-protected allylamines acrylamides which contain redox active ester group. The provides two C-C bonds in single operation takes place with both alkylzinc arylzinc bromides as nucleophiles. Activation RAE by low valent Ni complexes involving radical p...

The objective of this study was to observe the apoptosis-inducing effect and mechanism of baicalin on human cervical cancer HeLa cells. The inhibitory effect of baicalin on the growth of HeLa cells was measured by MTT assay, and cell proliferation and migration was analyzed by cell scratch assay. Morphological changes of apoptotic cells were viewed by the light microscope and electron microscop...

The objective of this study was to observe the apoptosis-inducing effect and mechanism of baicalin on human cervical cancer HeLa cells. The inhibitory effect of baicalin on the growth of HeLa cells was measured by MTT assay, and cell proliferation and migration was analyzed by cell scratch assay. Morphological changes of apoptotic cells were viewed by the light microscope and electron microscop...

We study the phase-controlled transmission properties in a compound system consisting of three-dimensional copper cavity and an yttrium-iron-garnet (YIG) sphere. By tuning relative phase magnon pumping cavity-probe tones, constructive destructive interferences occur periodically, which strongly modify both cavity-field spectra group delay light. Moreover, tunable amplitude ratio between pump-pr...