OBJECTIVES Activation of RhoA/Rho-kinase (ROCK) is increasingly implicated in acute vasospasm and chronic vasoconstriction in major organ systems. Therefore we aimed to ascertain whether an increase in ROCK activity plays a role in the deterioration of coronary vascular function in early stage diabetes. METHODS Synchrotron radiation microangiography was used to determine in vivo coronary resp...

Pancreatic cancer is one of the deadliest types of cancer, and despite extensive basic and pre-clinical research efforts, existing therapeutics remain largely ineffective. During pancreatic cancer progression, neoplastic transformation of epithelial cells is typically accompanied by a fibrotic response, driven by activation of stromal cells, and which leads to extensive deposition and remodelin...