A fatality involving cyamemazine, a phenothiazine derivative, is presented. Cyamemazine was formally identified in postmortem blood using an HPLC-DAD screening procedure, and then quantified in some postmortem samples by means of a specific HPLC method. The blood concentration of cyamemazine was 9.8 micrograms/mL. Tissue distribution of cyamemazine is discussed in light of the existing literature.

In ray Annual Reports to the London County Council I have published the results of an examination of the notified cases of scarlet fever and diphtheria in London, and which have led me to the conclusion that in these diseases there is seasonal variation both in fatality and age distribution. In the following Tables I give the results obtained from the use of the cases notified in the period 189...

BACKGROUND It is widely accepted that the shift in case-fatality rate between waves during the 1918 influenza pandemic was due to a genetic change in the virus. In animal models, the infectious dose of influenza A virus was associated to the severity of disease which lead us to propose a new hypothesis. We propose that the increase in the case-fatality rate can be explained by the dynamics of d...

CONTEXT Little is known about how state-level driver licensure laws, such as in-person renewal, vision tests, road tests, and the frequency of license renewal relate to the older driver traffic fatality rate. OBJECTIVE To determine whether state driver's license renewal policies are associated with the fatality rate among elderly drivers. DESIGN, SETTING, AND POPULATION Retrospective, longi...

A 19-year-old woman presented with status epilepticus and ventricular dysrhythmias less than one hour after ingesting 5,000 mg dimenhydrinate (Dramamine). Aggressive resuscitation including the use of physostigmine stabilized the cardiac rhythm; however, she suffered a severe neurologic deficit. Development of ischemic and infarcted bowel necessitated colonic resection. After surgery, her condi...

IN BRIEF •Over the past decade nonserious workplace injuries have decreased, but fatalities have decreased at a much slower rate. •Research shows that contributing factors are different between less-serious events and serious injury/fatality events. •Precursors to serious injuries and fatalities exist in most organizations and can be identified and measured. New paradigms are required to influe...

BACKGROUND The adherence to long tuberculosis (TB) treatment is a key factor in TB control programs. Always some patients abandon the treatment or die. The objective of this study is to identify factors associated with defaulting from or dying during antituberculosis treatment. METHODS Prospective study of a large cohort of TB cases diagnosed during 2006-2007 by 61 members of the Spanish Soci...