Tryptophan (TRP) and its neuroactive metabolite, kynurenic acid (KYNA), are thought to play key roles in central fatigue, but the specifics are still unknown. To clarify their roles in the brain, we developed a rat model of central fatigue induced by chronic sleep disorder (CFSD) by disturbing the sleep-wake cycle. Results showed that while 5-hydroxytryptamine (5-HT) concentration did not diffe...

Results are presented from an experimental program that recorded the outputs of strain gages mounted on two wheelchair frames (one manual, one power) as the wheelchairs were run on a double roller fatigue machine. Rectangular strain gage rosettes were attached to the frames near the cross tube center pin and on the side frame behind a front caster. Thirty data sets were recorded from each roset...

background: cancer is not merely an event with a certain end, but it is a permanent and vague situation that is determined by delayed effects due to the disease, its treatment and its related psychological issues. the aim of this study was to examine the effectiveness of the mindfulness-based stress reduction program and conscious yoga on the mental fatigue severity and life quality of women wi...

in the present study, the effect of various weight fractions of graphene nanoplatelet (gpl) on flexural fatigue behavior of epoxy polymer has been investigated at room temperature and generally the temperature was monitored on the surface of specimen during each test. the flexural stiffness of grapheme nano-platelet/epoxy nanocomposites at 0.1, 0.25 and 0.5 wt. % as a main effective parameter o...

PURPOSE The study aimed to investigate a relationship between the mineral content of human trabecular bone and parameters determined from compression fatigue tests at stepwise-increasing amplitude. METHODS Mineral content of trabecular bone was estimated comparing density and bone mineral density values. The relationship between the ash density, bone mineral density and factors obtained from ...

BACKGROUND AND PURPOSE Fatigue is frequent and important in the lives of Parkinson's disease (PD) patients. It is multidimensional, with physical and mental aspects. The aim of our study was to explore the impact of fatigue on quality of life (QoL) for PD patients. METHODS The sample consisted of 175 PD patients from Eastern Slovakia (52% males, mean age 68.2 +/- 9.2, mean disease duration 7....

Fatigue is often reported in stroke patients. However, it is still unclear if fatigue in stroke patients is more prominent, more frequent or more "typical" than in patients with multiple sclerosis (MS) and if the pathophysiology differs between these two populations. The purpose of this study was to compare motor fatigue and fatigue-induced changes in kinematic gait parameters between stroke pa...

The purpose of the present study was to evaluate the influence of acute fatigue of the hip flexor muscles on scores attained in tests frequently used in literature to measure hamstring muscle extensibility, namely the passive straight leg raise (PSLR), active straight leg raise (ASLR), passive knee extension (PKE), active knee extension (AKE), sit-and-reach (SR) and toe-touch (TT) tests. A tota...