Maladaptive fear, such as fear that is persistent or easily generalized to a nonthreatening stimuli, is associated with anxiety-related disorders in humans. In the laboratory, maladaptive fear can be modeled in rodents using Pavlovian fear conditioning. Recently, an inbred mouse strain known as 129S1/SvImJ, or 129S1 has been reported as exhibiting impairments in fear extinction and enhanced fea...

The three neurexins genes (NRXN1/2/3) encode polymorphic synaptic membrane proteins that are involved in cognitive functioning. Neurexins' selectivity of function is presumably conferred through differential use of 2 promoters and 5 alternative splicing sites (SS#1/2/3/4/5). In day-old rat brain neurons grown in culture, activation (depolarization) induces reversible, calcium dependent, repress...

the mesolimbic dopamine (da) system contains both d1-like and d2-like receptors, has been connected to control of locomotor behavior. an apparent role for d1 and d2 receptors throughout the mesolimbic system in the alteration of locomotor behavior has been demonstrated in pharmacological studies. the nucleus accumbens (nac) is comprised of a core and a shell subregion, which is a component of t...

There is no place on the Earth, the planet we live on, where the natural background radiation level is zero. Since the birth and even in our fetal stage, we have been exposed to different sources of natural radiation. Life, in fact, evolved in a radiation environment that was much more harsh than today. Earth serves as a source of terrestrial radiation. Uranium, thorium, and radium are among th...

background : one way to optimize energy consumption is replacing incandescent lamp with compact fluorescent lamps .these lamps produce ultraviolet radiation due to the nature of light production. this study aimed to evaluate the ultraviolet radiation emitted from compact fluorescent lamps which are widely used in iran. methods : this study carries out on 16 compact fluorescent lamps (four diffe...

The current radiation safety paradigm using the linear no-threshold (LNT) model is based on the premise that even the smallest amount of radiation may cause mutations increasing the risk of cancer. Autopsy studies have shown that the presence of cancer cells is not a decisive factor in the occurrence of clinical cancer. On the other hand, suppression of immune system more than doubles the cance...

BACKGROUND The startle reflex is potentiated by aversive states. It has been proposed that phasic startle potentiation to a threat cue and sustained startle potentiation to contextual stimuli reflect distinct processes mediated by different brain structures. The present study tested the hypothesis that alprazolam would reduce the sustained startle potentiation to contextual threats but not the ...

The purpose of the present survey was to review the important Non-pharmacologic treatments for fear of flying up to the present. This study is in the same way as some studies. Accordingly, some Non-pharmacologic treatments for fear of flying were assessed through this systematic review article. The general conclusion from the information provided by the  former studies, shows that a growing num...

Participants searched for discrepant fear-relevant pictures (snakes or spiders) in grid-pattern arrays of fear-irrelevant pictures belonging to the same category (flowers or mushrooms) and vice versa. Fear-relevant pictures were found more quickly than fear-irrelevant ones. Fear-relevant, but not fear-irrelevant, search was unaffected by the location of the target in the display and by the numb...

background: the health effect of rapidly increasing everyday exposure of humans to radiofrequency radiation is a major global concern. mobile phone jammers prevent the mobile phones from receiving signals from base stations by interfering with authorized mobile carriers’ services. in spite of the fact that mobile jammer use is illegal, they are occasionally used in offices, shrines, conference ...