Calorie restriction (CR) extends life span in a wide variety of species. Recent studies suggest that an increase in mitochondrial metabolism mediates CR-induced life span extension. Here we present evidence that Lat1 (dihydrolipoamide acetyltransferase), the E2 component of the mitochondrial pyruvate dehydrogenase complex, is a novel metabolic longevity factor in the CR pathway. Deleting the LA...

the antitumor activity of ethanol extract of prosopis glandulosa torr. (epg) was evaluated against ehrlich ascites carcinoma (eac) tumor model in swiss albino mice on dose dependent manner. the activity was assessed using survival time, average increase in body weight, hematological parameters and solid tumor volume. oral administration of epg at the dose of 100, 200 and 400 mg/kg, significantl...

Primary Health Care settings are unique in its nature because it deals with an entire family across the life span. Therefore, the primary care doctors may have also a unique opportunity in identifying and responding to cases of Violence Against Women (VAW) The different types of VAW experience have a significant negative impact on health and wellbeing not only on the female victim only but also...

The influence of blood meal and mating on Triatoma brasiliensis (Neiva) female fecundity, fertility, life-span and the preoviposition period were investigated under laboratory conditions. Nourishment increased fecundity, fertility and adult lifespan, whereas mating increased fecundity, fertility and decreased the preoviposition period. Females also required more than one mating to reach their f...

Genetic studies indicate that aging is modulated by a great number of genetic pathways. We have used Drosophila longevity and stress assays to test a multipath intervention strategy. To carry out this strategy, we supplemented the flies with herbal extracts (SC100) that are predicted to modulate the expression of many genes involved in aging and stress resistance, such as mTOR, NOS, NF-KappaB, ...