نتایج جستجو برای: ferritin

تعداد نتایج: 10628  

Journal: :Molecular vision 2004
Paul Hahn Tzvete Dentchev Ying Qian Tracey Rouault Z Leah Harris Joshua L Dunaief

PURPOSE CNS iron accumulation is associated with several neurodegenerative diseases, including age-related macular degeneration. Intracellular overload of free iron is prevented, in part, by the iron export protein, ferroportin, and the iron storage protein, ferritin. The purpose of this study was to assess retinal localization and regulation of ferroportin and ferritin. METHODS Normal murine...

2014
Kazuya Takasawa Naohisa Tomosugi Chikako Takaeda Teiryo Maeda Norishi Ueda

BACKGROUND/AIMS We examined whether regulation of hepcidin-25 by short- or long-acting recombinant human erythropoietin (rhEPO) is dependent on ferritin and predicts the response to rhEPO in hemodialysis (HD) patients. METHODS Two studies with rhEPO were performed in 9 HD patients with a 2-year interval. Serum hepcidin-25 was measured at 0-18 h after intravenous epoetin-β (EPO) or methoxy pol...

Journal: :BMB reports 2010
Jung Hwan Yoon Myeong Seon Lee Jung Hoon Kang

Lipid peroxidation is known to be an important factor in the pathologies of many diseases associated with oxidative stress. We assessed the lipid peroxidation induced by the reaction of ferritin with H2O2. When linoleic acid micelles or phosphatidyl choline liposomes were incubated with ferritin and H2O2, lipid peroxidation increased in the presence of ferritin and H2O2 in a concentration-depen...

2014
Soon Mi Hur Hye Young Ju Moo Yong Park Soo Jeong Choi Jin Kuk Kim Seung Duk Hwang

BACKGROUND/AIMS AIMS Inflammation is an important factor in renal injury. Ferritin, an inflammatory marker, is considered an independent predictor of rapid renal progression in patients with chronic kidney disease. However, the relationship between ferritin and residual renal function (RRF) in patients undergoing peritoneal dialysis (PD) remains unclear. METHODS We reviewed the medical rec...

2003
P. O. Berberat M. Katori E. Kaczmarek D. Anselmo C. Lassman B. Ke X. Shen R W. Busuttil Kenichiro Yamashita Eva Csizmadia Shivraj Tyagi Leo E. Otterbein S. Brouard E. Tobiasch F. H. Bach J. W. Kupiec-Weglinski M. P. Soares

Heme oxygenase-1 (HO-1) is induced under a variety of pro-oxidant conditions such as those associated with ischemia reperfusion injury (IRI) of transplanted organs. HO-1 cleaves the heme porphyrin ring releasing Fe, which induces the expression of the Fe sequestering protein ferritin. By limiting the ability of Fe to participate in the generation of free radicals through the Fenton reaction, fe...

Journal: :Blood 1996
D Gelvan E Fibach E G Meyron-Holtz A M Konijn

Iron delivery to mammalian cells is traditionally ascribed to diferric transferrin (Tf). We recently reported that human erythroid precursor cells possess specific membranes receptors that bind and internalize acid isoferritin. Here we show that ferritin uptake by these cells is highly regulated and that the internalized ferritin-iron is used for home synthesis and thus, this process could cons...

Journal: :The Plant journal : for cell and molecular biology 2002
Irene Murgia Massimo Delledonne Carlo Soave

Nitric oxide (NO) is a signaling molecule that plays a critical role in the activation of innate immune and inflammatory responses in animals. During the last few years, NO has also been detected in several plant species and the increasing number of reports on its function in plants have implicated NO as an important effector of growth, development and defense. Analogously to animals, NO has be...

Journal: :Gut 1997
J D Arnold A D Mumford J O Lindsay U Hegde M Hagan J R Hawkins

BACKGROUND Serum ferritin is normally a marker of iron overload. Ferritin genes are sited at chromosomes 19 and 11. Regulation of ferritin synthesis involves an interaction between an iron regulatory protein (IRP) and part of the ferritin mRNA designated the iron regulatory element (IRE). A disorder of ferritin synthesis resulting in hyperferritinaemia in the absence of iron overload has been d...

Journal: :Genetics 2007
Fanis Missirlis Stylianos Kosmidis Tom Brody Manos Mavrakis Sara Holmberg Ward F Odenwald Efthimios M C Skoulakis Tracey A Rouault

Ferritin is a symmetric, 24-subunit iron-storage complex assembled of H and L chains. It is found in bacteria, plants, and animals and in two classes of mutations in the human L-chain gene, resulting in hereditary hyperferritinemia cataract syndrome or in neuroferritinopathy. Here, we examined systemic and cellular ferritin regulation and trafficking in the model organism Drosophila melanogaste...

Journal: :European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1997
J ten Kate A Wolthuis B Westerhuis C van Deursen

In this paper we present a method for determining the iron saturation of ferritin as a possible independent predictor of iron stores. Serum ferritin was purified by immunochemical precipitation, and could be completely recovered from serum without any contamination from transferrin. The iron content of the precipitated ferritin was determined by flameless atomic absorption spectrophotometry (FA...

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