Birth asphyxia is a significant global health problem, responsible for ~1.2 million neonatal deaths each year worldwide. Those who survive often suffer from a range of health issues including brain damage-manifesting as cerebral palsy (CP)-respiratory insufficiency, cardiovascular collapse, and renal dysfunction, to name a few. Although the majority of research is directed toward reducing the b...

Liljeström, L. 2018. Birth asphyxia. Fetal scalp blood sampling and risk factors for hypoxic ischemic encephalopathy. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1435. 81 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0250-8. Preventing birth asphyxia is a major challenge in delivery care. The aims of this thesis were to evaluate fetal sca...

Background: Aortic stenosis (AS) is one of the degenerative heart lesions mainly resulting from congenital defects and rheumatic diseases. This study aimed to determine maternal fetal outcomes in pregnant women with moderate severe AS. Methods: The clinical data 26 AS treated between 2007 2019 Beijing Anzhen Hospital were collected retrospectively analyzed. Results: was diagnosed before pregnan...

The examination of birth asphyxia from a historical perspective presents several intriguing problems. First, of course, there is no satisfactory definition. Clinicians, biochemists and pathologists all seem to use the phrase, but a universal definition is lacking. Dr. Eastman of Hopkins called asphyxia "an infelicity of etymology" since the Greek derivation of asphyxia meant "without pulse." A ...

Key points Controversy exists about the physiological mechanism(s) underlying decreases in cardiac output after immediate clamping of umbilical cord at birth. To define these mechanisms, four major determinants ventricular (afterload, preload, heart rate and contractility) were measured concurrently fetal lambs 15 s intervals over a 2 min period before ventilation following delivery. After clam...

The classical concept of passage of meconium by the fetus in response to hypoxia and its association with poor fetal outcome is controversial. However, conventionally, the passage of meconium by the fetus has been taken as an indication for urgent delivery. Although its exact cause is not known, factors ranging from mesenteric vasoconstriction induced gut hyperperistalsis, falling umbilical ven...

Diving mammals share with fetal and newborn animals a high resistance to asphyxia when compared, respectively, with terrestrial and adult animals. Adaptations for conservation or sparing of oxygen and for adjustment to the effects of accumulated metabolic products, such as carbon dioxide and hydrogen ions, have been discovered in both diving marine mammals and asphyxiated terrestrial species. T...

OBJECTIVE To examine differences in outcomes between planned home births, occurring at home or in hospital, and planned hospital births. DESIGN AND SETTING Population-based study using South Australian perinatal data on all births and perinatal deaths during the period 1991-2006. Analysis included logistic regression adjusted for predictor variables and standardised perinatal mortality ratios...

BACKGROUND Determining cause of death is needed to develop strategies to reduce maternal death, stillbirth, and newborn death, especially for low-resource settings where 98% of deaths occur. Most existing classification systems are designed for high income settings where extensive testing is available. Verbal autopsy or audits, developed as an alternative, are time-intensive and not generally f...