OBJECTIVE Deep venous thrombosis is a major health problem. Thrombolytic therapies are effective in recanalizing the veins and preventing post-thrombotic complications, but there is no consensus on selection criteria. The aim of this study was to investigate a fibrin-specific MRI contrast agent (EP-2104R) for the accurate quantification of thrombus' fibrin content in vivo and for the identifica...

We tested a new rotational thrombectomy catheter in acute thrombi formed both in vitro and in vivo. The catheter consisted of a rounded platinum tip, 0.025 inch diameter by 0.08 inch long, attached to a flexible steel guidewire supported by an external sheath. In vitro, the force required to penetrate thrombus was reduced fivefold by rotation of the catheter at 4000 rpm (0.75 +/- 1.2 g rotating...

Thrombus formation (thrombogenesis) is a process involving platelet adherence to the vessel wall (sometimes at sites of endothelial injury), platelet aggregation and release, thrombin generation and fibrin formation. In addition, it is also well recognized that the process of atherosclerosis is closely related to ongoing formation and organization of mural thrombi [ l , 21. Improved biochemical...

This article is a summary of the Sol Sherry Lecture of the Council on Arteriosclerosis, Thrombosis, and Vascular Biology, which was presented at the 71st Scientific Sessions of the American Heart Association in November 1998.1 It highlights the work from our laboratory, designed to dissect the intricate reactions and molecular control mechanisms that operate in the final stages of the coagulati...

We tested a new rotational thrombectomy catheter in acute thrombi formed both in vitro and in vivo. The catheter consisted of a rounded platinum tip, 0.025 inch diameter by 0.08 inch long, attached to a flexible steel guidewire supported by an external sheath. In vitro, the force required to penetrate thrombus was reduced fivefold by rotation of the catheter at 4000 rpm (0.75 + 1.2 g rotating v...

BACKGROUND The T2G1s monoclonal antifibrin antibody binds specifically to fibrin but not to fibrinogen. METHODS AND RESULTS In a canine model of acute arterial thrombosis, we determined the feasibility of imaging thrombi using a 99mTc-labeled Fab' fragment. In 14 dogs, 10 carotid and 13 femoral artery thrombi were produced using 2-hour temporary occlusion, crush injury, and local thrombin inj...

AIMS Recent studies have demonstrated that erythrocytes are a potential component in atheromatous lesions and thrombus formation in patients with ST-elevation myocardial infarction (STEMI). The purpose of this study was to determine the associations of red blood cell (RBC) component of coronary thrombi with oxidative stress and myocardial reperfusion. METHODS AND RESULTS Aspirated thrombi fro...

AIM Thrombus formation is a dynamic process regulated by flow, blood cells, and plasma proteins. The present study was performed to investigate the characteristics of human coronary thrombus in ST-segment elevation myocardial infarction (STEMI). METHODS AND RESULTS Patients admitted with ST-elevation myocardial infarction, in which thrombectomy was performed, were included (n = 86). Intracoro...

BACKGROUND Although diabetes mellitus (DM) is a predictor of poor outcomes in patients with ST-segment elevation myocardial infarction (STEMI), few studies have analyzed the impact of DM on the constituency of coronary thrombi. OBJECTIVES Comparing morphologic and histopathologic aspects of coronary thrombi in STEMI patients with and without DM who underwent primary percutaneous coronary inte...