In certain circumstances, superimposed interharmonics in the supply voltage can lead to oscillating luminous flux and cause light flicker. This phenomenon can be observed with filament lamps as well as with fluorescent lamps. Different items are dealt with in this paper: § Presentation of some experimental results: determination of the sensitivity curves for different types of lighting devices,...

Plasma pharmacokinetics of ST-246, smallpox therapeutic, was evaluated in mice, rabbits, monkeys and dogs following repeat oral administrations by gavage. The dog showed the lowest Tmax of 0.83 h and the monkey, the highest value of 3.25 h. A 2- to 4-fold greater dose-normalized Cmax was observed for the dog compared to the other species. The mouse showed the highest dose-normalized AUC, which ...

Introduction Cells need oxygen for mitochondrial respiration and a wide range of other metabolic processes. It is increasingly being recognized that there are sophisticated mechanisms for monitoring local oxygenation and that these are used to modulate extensive aspects of cellular behaviour. This excellent meeting was held at 9,600 feet where oxygen is 70% of that at sea level; enough to cause...

PRM-151, recombinant human Pentraxin-2 (PTX-2) also referred to as serum amyloid P (SAP), is under development for treatment of fibrosis. A First-in-Human (FIH) trial was performed to assess the safety, tolerability, and pharmacokinetics of single ascending intravenous doses of PRM-151 administered to healthy subjects, using a randomized, blinded, placebo controlled study design. Each cohort in...

Among the many challenges facing institutional review boards (IRBs) is to predict whether the activities and interventions proposed in a clinical trial protocol are likely to yield net harm or net benefit for trial participants. IRBs take these questions very seriously, and never more so than in the review of first-inhuman (FIH) trials, where interpreting findings about risks to humans from ani...

In the history of flavin (bio)chemistry the "fully reduced state" (Flred) has drawn the least attention, as compared to the oxidized state ("flavoquinone," Flox ) and the radical state ("flavosemiquinone," FI). The reason for this is to be found not so much in the realm of science, but in the psychology of scientists: Flred does not exhibit an optical spectrum as distinctive as Flox , and even ...

Madam, Postpartum haemorrhage (PPH), defined as postpartum blood loss of > 1000 mL, is a life-threatening emergency and the leading cause maternal mortality accounting for 25% deaths worldwide (1). PPH can lead to significant morbidity, including shock, ARDS, coagulopathy, infertility due hysterectomy, even (4). Uterine atony most common cause, 80% all cases (1) (2). Active management third ...