We report here the first identification of the worldwide spread of Klebsiella pneumoniae carbapenemase-2-producing and carbapenem-resistant K. pneumoniae clone ST258 in Turkey, a country where the distantly-related carbapenemase OXA-48 is known to be endemic. Worryingly, this isolate was also resistant to colistin, now considered to be the last-resort antibiotic for carbapenem-resistant isolates.

The measurement of myocardial performance is of critical importance for the diagnosis and management of the patient with cardiac disease. Despite decades of investigation, the search for the optimal method to measure the contractile properties of the myocardium still continues. Extrapolations from experiments in isolated muscle preparations and the intact animal heart have resulted in invasive ...

Currently, two different solutions for filesystems on flash storage exist: Flash Translation Layers in combination with traditional filesystems and log-structured flash file systems. This paper analyzes the weaknesses of both approaches and derives a number of requirements that help avoiding these weaknesses. Finally the basic concept of a tree structured flash file system fulfilling all of the...

n engl j med 373;24 nejm.org december 10, 2015 2296 Another set of proposed changes aims to match the level of oversight to the level of risk the research poses to participants, by defining categories of research that are excluded from the Common Rule or are exempt from one or more of its requirements (e.g., IRB review). The excluded categories are activities that are deemed not to meet the rul...

For decades, investigators have made numerous attempts to generate human pancreatic β cell lines that could be used to advance β cell biology, facilitate drug discovery, and provide a pathway to β cell replacement therapy for the treatment of diabetes. In this issue of the JCI, Ravassard and colleagues report that this has finally been achieved successfully with a multistep process that led to ...