Flavonoids have been suggested to play a chemopreventive role in carcinogenesis. However, the epidemiologic studies assessing dietary intake of flavonoids and esophageal cancer risk have yielded inconsistent results. This study was designed to examine the association between flavonoids, each flavonoid subclass, and the risk of esophageal cancer with a meta-analysis approach. We searched for all...

BACKGROUND Flavonoids are a group of phenolic secondary plant metabolites that are ubiquitous in plant-based diets. Data from anthropological, observational and intervention studies have shown that many flavonoids are bioactive. For this reason, there is an increasing interest in investigating the potential health effects of these compounds. The translation of these findings into the context of...

The alkenylbenzene estragole is a constituent of several herbs and spices. It induces hepatomas in rodents at high doses following bioactivation by cytochrome P450s and sulfotransferases (SULTs) giving rise to the ultimate carcinogenic metabolite 1'-sulfooxyestragole which forms DNA adducts. Methanolic extracts from different alkenylbenzene-containing herbs and spices were able to inhibit SULT ...

Lotus leaf has gained growing popularity as an ingredient in herbal formulations due to its various activities. As main functional components of lotus leaf, the difference in structure of flavonoids affected their binding properties and activities. In this paper, the existence of 11 flavonoids in lotus leaf extract was confirmed by High Performance Liquid Chromatography (HPLC) analysis and 11 f...

Molecular docking is a frequently used tool in computer-aided structure-based rational drug design. Flavonoids are a group of natural products which exhibits various biological and pharmacological activities. The primary objective of this study was to investigate the aldose reductase inhibitory activity of flavonoids using in silico docking studies. In this perspective, flavonoids like aromaded...

The cell suspension cultures were established from leaf, fruit and root explants of Indian Mulberry (Morinda citrifolia) for the production of medicinally important secondary metabolites, anthraquinones, flavonoids and phenolics and the effect of subculture on these secondary metabolites was studied. The MS medium formulated with NAA, BA and Kinetin was found to be effective to produce anthraqu...

flavonoids could serve as potent inhibitors of xanthine oxidase (xo). in the present study, the effects of ruta graveolens l. extract and its major isolated flavonoids, quercetin and rutin, on guinea pig liver xo have been investigated. the inhibitory effects of r. graveolens, quercetin and its glycoside form, rutin, were assayed spectrophotometrically. r. graveolens extract showed moderate inh...

Flavonoids are potential antibacterial agents. However, key substituents and mechanism for their antibacterial activity have not been fully investigated. The quantitative structure-activity relationship (QSAR) and molecular docking of flavonoids relating to potent anti-Escherichia coli agents were investigated. Comparative molecular field analysis (CoMFA) and comparative molecular similarity in...

This study was undertaken to compare the levels of ascorbic acid, vitamin C, flavonoids, nitrate, and oxalate in 27 spinach varieties grown in certified organic and conventional cropping systems. Liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-(ESI)MS/MS) of methanolic extracts of spinach demonstrated 17 flavonoids, including glucuronides and acylated di- and triglyco...

Flavonoids are phytochemicals which can regulate the activity of the intestinal immune system. In patients with chronic inflammatory bowel disease (IBD) there is an overexpression and imbalance of the components of the inflammatory immune reactions which are chronically activated. Suppression of inflammation can be achieved by anti-inflammatory drugs which are used in clinical medicine but thes...