The environment created on Earth within a clinostat or Rotating Wall Vessel (RWV) bioreactor is often referred to as "simulated microgravity". Both devices utilize constant reorientation to effectively nullify cumulative sedimentation of particles. Neither, however, can fully reproduce the concurrent lack of structural deformation, displacement of intercellular components and/or reduced mass tr...

This work reports on an evaluation of the computational fluid dynamics–discrete element method (CFD-DEM) numerical approach to study behavior polymer-filled suspensions in a parallel-plate rheometer. For this purpose, open-source CFD-DEM solver is used model such considering different particle volume fractions and types rheology. We first validate for single-phase flow continuum phase (fluid ph...

A numerically effective approach was developed for the modeling of spray-drying colloidal suspensions. This based on integration two models. The first is a phenomenological and radially symmetric model accounting drying single-droplets, while second employs computational fluid dynamics (CFD) simulations to account gas flow conditions atomization in spray dryer. Experiments were also conducted s...

Multifunctional nanomedicine holds considerable promise as the next generation of medicine that allows for targeted therapy with minimal toxicity. Most current studies on Nanoparticle (NP) drug delivery consider a Newtonian fluid with suspending NPs. However, blood is a complex biological fluid composed of deformable cells, proteins, platelets, and plasma. For blood flow in capillaries, arterio...

Accurately resolving the coupled momentum transfer between liquid and solid phases of complex fluids is a fundamental problem in multiphase transport processes, such as hydraulic fracture operations. Specifically we need to characterize dependence normalized average fluid–particle force $$\langle F \rangle$$ on volume fraction dispersed phase rheology fluid matrix, parameterized through Weissen...

In the current literature, information can mainly be found about free and hindered settling of isometric particles in Newtonian non-Newtonian fluids. These conclusions cannot used to describe sedimentation non-isometric particle For this reason, we have carried out systematic experiments calculated correlation velocity a cloud high-viscosity pseudoplastic liquid. The were performed transparent ...

This paper describes an improved microfluidic device that enables hydrodynamic particle concentration and size-dependent separation to be carried out in a continuous manner. In our previous study, a method for hydrodynamic filtration and sorting of particles was proposed using a microchannel having multiple branch points and side channels, and it was applied for continuous concentration and sep...

Mixing and dispersion of solids and gases in liquids in mechanically agitated reactors is involved in about 80% of the operations in the chemical industries, including processes ranging from leaching and complete dissolution of reagents to suspension of catalysts and reaction products, such as precipitates and crystals (Smith, 1990). This is one of the most widely used unit operations because o...

Granular materials whether dry or immersed in fluid show dilation compaction depending upon the initial conditions, solid fraction and normal stress. Here we probe transient response of a dense granular suspension subjected to change applied stress under simple shear. In this aim, normal-stress-imposed discrete element particle simulations are developed considering contributions arising from dr...