Fluorination has gained an increasingly important role in drug discovery and development. Here we describe a versatile strategy that combines cytochrome P450–catalyzed oxygenation with deoxofluorination to achieve monoand polyfluorination of nonreactive sites in a variety of organic scaffolds. This procedure was applied for the rapid identification of fluorinated drug derivatives with enhanced ...

The air and moisture stable fluoroiodane 8, readily prepared on a 6 g scale by nucleophilic fluorination of the hydroxyiodane 7 with TREAT-HF, has been used as an electrophilic fluorinating reagent for the first time to monofluorinate 1,3-ketoesters and difluorinate 1,3-diketones in good isolated yields.

A facile method for the synthesis of highly fluorinated reduced graphene oxide from graphene oxide using BF3-OEt2 solution and alkylthiol/alkylamine on the Gram scale has been described using a detailed mechanism. The maximum fluorination was as high as 38 wt% and the fluorinated reduced graphene oxide produced has great wettability and high insulating properties.

Preliminary validation of cyclopropene activation by an I(I)/I(III) catalysis manifold is disclosed to enable the direct tetrafluorination 3,3-diarylcyclopropenes. This transformation occurs through in situ generation ArI(III)F2, with inexpensive iodobenzene, amine·HF complexes and Selectfluor® serving as catalyst, fluoride source oxidant, respectively. Leveraging this approach, it has been pos...

This work aims to obtain the dispersions based on polyethylene glycols (PEGs) of various molecular masses (MM) and perfluorodecalin (PFD) for subsequent direct fluorination. The solubility components was estimated using laser interferometry differential scanning calorimetry, it shown that PEGs with different MM are not highly compatible PFD. were prepared during sonication. Gel permeation chrom...