Using 18F-fluorodeoxyglucose and 11C-diprenorphine positron emission tomography (PET), we investigated alterations in glucose metabolism and opioid receptor binding in a patient with central poststroke pain, which developed after a small pontine hemorrhagic infarction. In comparison with normal databases, reduced 11C-diprenorphine binding was more accentuated than the hypometabolism on the late...

This study aimed to investigate the influence of apolipoprotein E (APOE) ε4 allele on whole-brain functional networks in cognitively normal (CN) elderly by applying graph theoretical analysis to brain glucose metabolism. Eighty-six CN elderly [28 APOE ε4 carriers (ε4+) and 58 non-carriers (ε4-)] underwent clinical evaluation and resting [(18)F] fluorodeoxyglucose positron emission tomography sc...

T he paper by Bonow et al' in this issue of Circulation reports important empirical observations on measuring myocardial viability in humans with the potassium analogue thallium-201. After obtaining standard 20'1f exercise and redistribution images, a second dose of 201TI was injected and a third (reinjection) image was obtained beginning 10-15 minutes later. The reinjection images identified v...

BACKGROUND The standardized uptake value (SUV) is the most common estimate of metabolic activity used in clinical positron emission tomography (PET). Several biological and technological factors influence the accurate SUV calculation. PURPOSE To assess another potential source of variability of the SUV, the variations in urinary excretion of fluorodeoxyglucose (FDG). MATERIAL AND METHODS Tw...

BACKGROUND To evaluate the impact of 18F-FDG PET/CT on target volume delineation in gynaecological cancer. METHODS F-FDG PET/CT based RT treatment planning was performed in 10 patients with locally recurrent (n = 5) or post-surgical residual gynaecological cancer (n = 5). The gross tumor volume (GTV) was defined by 4 experienced radiation oncologists first using contrast enhanced CT (GTVCT) a...

Fluorodeoxyglucose positron emission tomography ((18)FDG-PET) is currently the best noninvasive test to confirm hepatic metastases when diagnostic uncertainty exists after initial imaging with first-line modalities. However, we report the second case of "false-positive" uptake of (18)FDG on PET scanning from a histopathologically confirmed hepatic adenoma.

OBJECTIVE The aim of this study was to assess the diagnostic efficacy of integrated PET/CT using fluorodeoxyglucose (FDG) for the differentiation of benign and metastatic adrenal gland lesions in patients with lung cancer and to compare the diagnostic efficacy with the use of PET alone. MATERIALS AND METHODS Sixty-one adrenal lesions (size range, 5-104 mm; mean size, 16 mm) were evaluated ret...

Using (18)F-fluorodeoxyglucose microPET imaging, we investigated the neurocircuitry of contextual anxiety versus control in awake, conditioned rats (n = 7-10 per group). In addition, we imaged a group expressing cued fear. Simultaneous measurements of startle amplitude and freezing time were used to assess conditioning. To the best of our knowledge, no neuroimaging studies in conditioned rats h...

OBJECTIVE To evaluate the role of plasma clusterin in Alzheimer's disease (AD). BACKGROUND Plasma clusterin is a promising biomarker as various studies have shown it to be associated with AD. But other studies have shown that plasma clusterin levels were not related to Alzheimer's disease or presymptomatic AD. Hence the diagnostic value of plasma clusterin is still not conclusive. METHODS N...

E. G. Steffensen, V. Prakash, S. F. Eskildsen, K. Vestergård, V. V. Iyer, and E-M. Larsson Department of Radiology, Aalborg Hospital/Århus University Hospital, Aalborg, Denmark, Department of Nuclear Medicine, Aalborg Hospital/Århus University Hospital, Aalborg, Denmark, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Neurology, Aalborg Hospital/...