Chronic pruritus is difficult to treat and requires the evaluation of new therapeutic modalities. We initiated an open-labelled, two-arm prospective, proof-of-concept study applying two selective serotonin re-uptake inhibitors on a long-term basis. Paroxetine and fluvoxamine were tested in a total of 72 pruritic patients (27 men, 45 women, age range 28-88 years, mean age 59.2 years). The reduct...

Background.A review of the efficacy of antidepressantdrug treatment in patients with obsessive—compulsive disorder(OCD), usinga meta-analyticapproach. Method. Randomiseddouble-blindclinicaltrialsof antidepressantdrugs,carriedout among patients with OCD and publishedin peer-reviewedjournalsbetween 1975 and May 1994, were selectedtogetherwith three studiescurrentlyin press.Forty-seventrialswere...

Pharmacokinetic drug-drug interactions often occur at the level of P-glycoprotein (Pgp). To study possible interactions caused by the newer antidepressants we investigated citalopram, fluoxetine, fluvoxamine, paroxetine, reboxetine, sertraline, and venlafaxine and their major metabolites desmethylcitalopram, norfluoxetine, paroxetine-metabolite (paroxetine-M), desmethylsertraline, N-desmethylve...

A 43-year old woman and a 41-year-old man both had a long history of antipsychotic treatment for schizophrenia, and both experienced tardive dyskinesia. The patients had 100 mg/day fluvoxamine added to their antipsychotic regimens in an attempt to control the dyskinesia. Within 4 weeks, both patients experienced substantial declines in Abnormal Involuntary Movement Scale scores: from 6 to 2 in ...