BACKGROUND Septin9 is a member of GTP-binding protein family, and is used as a predictive diagnostic index. However, it has not been widely adopted due to inconsistent results reported in the literature. The present study was performed to determine the diagnostic accuracy of methylated Septin9 (mSEPT9) for colorectal cancer (CRC) and to evaluate its utility in CRC screening. MATERIAL AND METHOD...

Colorectal cancer (CRC) screening is a cost-effective prevention and control strategy. However, the promotion of CRC screening for older adults may be difficult because reading CRC prevention information may evoke embarrassment, fear, and anxiety towards the screening procedure and cancer diagnosis. This study aims to (1) examine the effects of three promotional materials for CRC screening on t...

BACKGROUND Follow-up after a positive colorectal cancer screening test is necessary for screening to be effective. We hypothesized that nurse navigation would increase the completion of colonoscopy after a positive screening test. METHODS This study was conducted between 2008 and 2012 at 21 primary care medical centers in western Washington State. Participants in the Systems of Support to Inc...

BACKGROUND Little is known about the psychological predictors of colorectal screening uptake in England and mediators of associations between uptake and socioeconomic status (SES). This study tested the hypotheses that although higher threat and efficacy beliefs, lower cancer fatalism, lower depression, and better self-rated health would predict higher screening uptake, only efficacy beliefs, f...

BACKGROUND An increasing proportion of colorectal cancer (CRC) patients are diagnosed by screening rather than symptoms. AIMS We aimed to assess and compare prognosis of patients with screen-detected CRC and symptom-detected CRC. METHODS Overall and CRC specific mortality over a median follow-up of 4.8 years was assessed according to mode of diagnosis (symptoms, screening colonoscopy, fecal...

BACKGROUND We (i) described variability in colorectal cancer (CRC) test use across multiple levels, including physician, clinic, and neighborhood; and (ii) compared the performance of novel cross-classified models versus traditional hierarchical models. METHODS We examined multilevel variation in CRC test use among patients not up-to-date with screening in a large, urban safety net health sys...

156 British Journal of General Practice, March 2015 BaCkground and advantages over exIstIng teCHnology A variety of home-use faecal occult blood testing (FOBt) kits remain commercially available to UK patients despite caution regarding their safety and accuracy. FOBt is a relatively non-invasive and inexpensive test. The NHS Bowel Cancer Screening Programme (BCSP) and the majority of European s...

The aims of the present study was to determine whether or not abomasal damages occurs in calves with abdominal distention using by plasma pepsinogen levels and positivity fecal occult blood test (FOBT). In study, 30 (distention group) 15 clinically healthy (control group), aged between 1-90 days, were used. Collected samples all used levels, bovine specific ELISA. Fresh stool also taken from re...