Endothelial surface expression of P-selectin and subsequent leukocyte rolling in venules can be induced by mast cell-derived histamine and binding of thrombin to protease-activated receptor-1 (PAR1). We hypothesized that activation of endothelial PAR2 by mast cell tryptase or other proteases also contributes to inflammatory responses. Leukocyte rolling flux and rolling velocity were assessed by...

2014 The energy straggling of heavy ion beams at tandem energies, passing through thin foils, has been studied with ions of mass up to A = 35. Charge exchange in the foils has been found to have a considerable effect on the energy spread. Thickness non-uniformities in the foils can also make significant contributions. Extrapolation of the observations to the case of a uniform carbon stripper fo...

Introduction: The velocity distribution of impact ejecta from regolith-like target has been investigated in laboratory for nearly three decades. For the case of vertical impact, the ejecta velocity distribution is determined experimentally and given by a power-law with an exponent of –1.22 [1]. There is an upper limit to the ejecta velocity (Hartmann cutoff velocity) that depends on impact velo...

austenite is a semi-stable phase in most stainless steels that deforms to martensite under md30 and forms martensitetype ά and ε due to the deformation in the steels. since the distribution of strain induced martensite plays animportant role in achieving desired properties, the main objective of the present work is to model martensitedistribution of ά during cold rolling using finite element me...

Rolling allows leukocytes to maintain adhesion to vascular endothelium and to molecularly coated surfaces in flow chambers. Using insights from adhesive dynamics, a computational method for simulating leukocyte rolling and firm adhesion, we have developed a semianalytic model for the steady-state rolling of a leukocyte. After formation in a force-free region of the contact zone, receptor-ligand...

Leukocyte rolling along the walls of inflamed venules precedes their adhesion during inflammation. Rolling leukocytes are thought to arrest by engaging beta2 integrins following cellular activation. In vitro studies suggest that chemoattractants may instantaneously activate and arrest rolling leukocytes. However, how leukocytes stop rolling and become adherent in inflamed venules in vivo has re...

In this study, we tested the hypothesis that reducing shear rates in postcapillary venules causes CD18-dependent, selectin-independent leukocyte rolling. Intravital microscopy was used to assess shear rate-dependent leukocyte rolling in 25- to 40-microns rat mesenteric venules. Pretreatment of animals with 25 mg/kg fucoidin, a carbohydrate moiety that binds to and inhibits selectin function, es...

In order to achieve the nonsmooth surface drag reduction structure on the inner polymer coating of oil and gas pipelines and improve the efficiency of pipeline transport, a structural model of the machining robot on the pipe inner coating is established. Based on machining robot, an experimental technique is applied to research embossing and coating problems of rolling-head, and then the moldin...

Fully stripped heavy ion beam of a nearly relativistic energy and a super high intensity is supposed to be accumulated in the storage ring of ITEP-TWAC Facility that is under construction at ITEP on the base of existing accelerators. Nonliouvillean multiturn injection technique is elaborated to store in the accumulator ring as much as one thousand batches, which are accelerated in the booster s...