Abstract Study question Is FMR1 (Fragile-X-Mental Retardation 1 Gene)-targeting miR-323a related to poor ovarian response and what impact does it have on the folliculogenesis-regulating SMAD-signaling pathway? Summary answer In responders, is significantly upregulated, FMRP – downregulated. Human granulosa cells, transfected with a mimic, show an upregulation of SMAD proteins. What known alread...
