OBJECTIVE To investigate the behavioral characteristics, including anxiety and motor impairment, in sodium benzoate (NaB) treated rats. METHODS The study was carried out between July and September 2012 in the Laboratory Animal Center of Shiraz University of Medical Sciences, Shiraz, Iran. The rats were divided into 2 groups receiving distilled water and NaB (200mg/kg/day). All the animals rec...

OBJECTIVE To measure the influence of topical steroids and the preservative potassium sorbate on the ciliary beat frequency (CBF) of human nasal mucosa in vitro. DESIGN In vitro study of cultured ciliated cells of human nasal mucosa. METHODS Human nasal mucosa was removed endoscopically and cultured for 10 days. Cell cultures with ciliated cells grown on an object slide were exposed to benz...

Timolol (generic name) is a frequently used medication for the control of glaucoma. Benzalkonium chloride (BAK) is a commonly used preservative in ophthalmic solutions with a broad range of antimicrobial activity; however, this nonspecificity can result in toxicity. Adverse effects attributed to BAK, including conjunctival inflammation and fibrosis, tear film instability, corneal cytotoxicity, ...

Preservative-treated wood is an economical, durable, and aesthetically pleasing building material; therefore, it is a natural choice for construction projects in our National Forests, National Parks, and other public lands. However, we need to ensure that the chemicals used in treated wood do not pose a threat to people or the environment. The purpose of this report is to provide a summary of t...

OBJECTIVES To assess microbial contamination of common non-preservative eye drops stored at 4 degrees C and non-preservative fortified antibiotic eye drops used in a hospital inpatient setting. MATERIAL AND METHOD A prospective study of the sterility of non-preservative eye drops was examined by dividing the patients into 2 groups. Group 1 composed of 5 samples of each ophthalmic preparation,...

BACKGROUND Efficacy, tolerability and safety of the novel preservative-free fixed combination of tafluprost 0.0015%/timolol 0.5% (Taptiqom®) were investigated in an observational study in Germany. OBJECTIVE To assess efficacy, tolerability and safety of the preservative-free fixed combination of tafluprost 0.0015%/timolol 0.5% in a real-life setting. METHODS Intraocular pressure (IOP) was r...

PURPOSE To examine the expression pattern of the stress-related genes c-fos and c-jun, which encode the 2 major components of activator protein (AP)-1, and cyclooxygenase (COX)-2 in rat corneal epithelium treated with topical antiglaucoma medications and benzalkonium chloride (BAK) preservative. METHODS Eighty-eight male Wistar rats were used. We instilled antiglaucoma eye drops (0.5% Timopto...

This review discusses the status, antimicrobial mechanisms, application, and regulation of natural preservatives in livestock food systems. Conventional preservatives are synthetic chemical substances including nitrates/nitrites, sulfites, sodium benzoate, propyl gallate, and potassium sorbate. The use of artificial preservatives is being reconsidered because of concerns relating to headache, a...

Foodborne infections cause substantial issues all around the world, hence food safety is a major public health concern. The goal of this research to provide information scientific community on possible application two plant essential oil molecules, Carvacrol (CAR) and Cinnamaldehyde (CN), as next-generation antimicrobials in fight against foodborne pathogens. CAR CN demonstrated outstanding dos...

Stevia rebaudiana Bertoni, is an ancient perennial shrub of South America, with great potential as a crop for the production of high-power natural sweetener. Due to its chemical composition and content of the phytochemical compounds, it is suitable as a raw material for the extraction and production of functional foods. Diterpene glycosides component of low-calorie sweetener is approximately 30...